X0306 4 2022-06-27 0 0001680581 Fulcrum Therapeutics, Inc. FULC 0001239746 GERAGHTY JAMES A C/O FULCRUM THERAPEUTICS, INC. 26 LANDSDOWNE STREET CAMBRIDGE MA 02139 1 0 0 0 Stock Option (right to buy) 5.22 2022-06-27 4 A 0 19000 0.00 A 2032-06-26 Common Stock 19000 19000 D This option was granted on June 27, 2022 and is scheduled to vest with respect to all shares on the first anniversary of the grant date or, if earlier, immediately prior to the first annual meeting of stockholders occurring after the grant date, subject to continued service. Exhibit Index: 24.1 Power of Attorney /s/ Greg Tourangeau, as attorney-in-fact for James A. Geraghty 2022-06-29