As filed with the Securities and Exchange Commission on June 18, 2018

Registration No. 333-215026

UNITED STATES

 SECURITIES AND EXCHANGE COMMISSION

 Washington, D.C. 20549

POST-EFFECTIVE AMENDMENT NO. 1 TO

 FORM S-8

REGISTRATION STATEMENT 

UNDER 

THE SECURITIES ACT OF 1933

SENESTECH, INC.
(Exact name of Registrant as specified in its charter)

Delaware	20-2079805
(State or other jurisdiction of incorporation or organization)	(I.R.S. Employer Identification No.)

3140 N. Caden Court, Suite 1 

Flagstaff, AZ 86004 

(928) 779-4143 

(Address of Principal Executive Offices, including zip code)

SENESTECH, INC. 2008-2009 NON-QUALIFIED STOCK OPTION PLAN

 SENESTECH, INC. 2015 EQUITY INCENTIVE PLAN

SENESTECH, INC. 2018 EQUITY INCENTIVE PLAN

 (Full title of the plan)

Loretta P. Mayer, Ph.D. 

Chair of the Board, Chief Executive Officer and Chief Scientific Officer 

SenesTech, Inc. 

3140 N. Caden Court, Suite 1 

Flagstaff, AZ 86004 

(928) 779-4143 

(Name, address, including zip code and telephone number, including area code, of agent for service)

Copy to:  

Danielle Benderly
Perkins Coie LLP
1120 NW Couch Street, Tenth Floor 

Portland, Oregon 97209-4128 

503-727-2000

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, a smaller reporting company, or an emerging growth company. See the definitions of “large accelerated filer,” “accelerated filer,” “smaller reporting company,” and “emerging growth company” in Rule 12b-2 of the Exchange Act.

Large accelerated filer ☐	Non-accelerated filer ☐	Smaller reporting company ☒
Accelerated filer  ☐	(Do not check if a smaller reporting company)	Emerging growth company ☒

If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 7(a)(2)(B) of the Securities Act. ☒

CALCULATION OF REGISTRATION FEE

Title of Securities to Be Registered (1)	Amount to Be Registered(2)	Proposed Maximum Offering Price Per Share(3)	Proposed Maximum Aggregate Offering Price(3)	Amount of Registration Fee(3)
Common Stock, $0.001 par value, under the SenesTech, Inc. 2008-2009 Non-Qualified Stock Option Plan, the SenesTech, Inc. 2015 Equity Incentive Plan and to the extent specified herein, the SenesTech, Inc. 2018 Equity Incentive Plan	2,996,000 shares	N/A	N/A	N/A

(1) As described in the Explanatory Note below, this Post-Effective Amendment No. 1 to Registration Statement on Form S-8 (this “Post-Effective Amendment”) is being filed to provide that up to 2,874,280 shares of common stock originally registered upon filing of the Registration Statement on Form S-8 (File No. 333-215026) filed with the Securities and Exchange Commission on December 9, 2016 (the “Prior Registration Statement”) for issuance under the SenesTech, Inc. 2015 Equity Incentive Plan (the “2015 Plan”) may be issued under the SenesTech, Inc. 2018 Equity Incentive Plan (the “2018 Plan” and together with the 2015 Plan, the “Plans”) once they are no longer issuable pursuant to the 2015 Plan.

(2) Pursuant to Rule 416(c) under the Securities Act, includes an indeterminate number of additional shares which may be necessary to adjust the number of shares issued pursuant to the plans as the result of any future stock split, stock dividend or similar adjustment of our outstanding common stock.

(3) The filing fee for the registration of the offer of shares of common stock under the SenesTech, Inc. 2008-2009 Non-Qualified Stock Option Plan and the SenesTech Inc. 2015 Equity Incentive Plan was paid in full upon the filing of the Prior Registration Statement. Pursuant to SEC Compliance and Disclosure Interpretation 126.43, no filing fee is required for this Post-Effective Amendment.

EXPLANATORY NOTE

SenesTech, Inc. (the “Registrant”) previously filed its Registration Statement on Form S-8 (File No. 333-215026) with the Securities and Exchange Commission (the “Commission”) on December 9, 2016 (the “Prior Registration Statement”) with respect to 2,996,000 shares of the Registrant’s common stock, par value $0.001 per share (the “Common Stock”), issuable under the Registrant’s 2008-2009 Non-Qualified Stock Option Plan (the “2008-2009 Plan”) and the Registrant’s 2015 Equity Incentive Plan (the “2015 Plan”).

On June 12, 2018 (the “Approval Date”), the Registrant’s stockholders approved the Registrant’s 2018 Equity Incentive Plan (the “2018 Plan”) and, in connection therewith, no further awards will be made under the 2015 Plan. Pursuant to the terms of the 2018 Plan, any shares currently reserved for issuance under the 2015 Plan and any shares that were subject to outstanding awards under the 2015 Plan as of the Approval Date that subsequently cease to be subject to such awards as a result of the forfeiture, cancellation or termination of such awards will become available for issuance under the 2018 Plan (the “Rollover Shares”).

The Company is filing this Post-Effective Amendment No. 1 to Form S-8 (the “Amendment”) pursuant to SEC Compliance and Disclosure Interpretation 126.43 to amend the Prior Registration Statement to also cover the offer and sale of up to 2,874,280 Rollover Shares under the 2018 Plan (to the extent such shares are, or become no longer issuable under the 2015 Plan and instead are, or become issuable under the 2018 Plan). For avoidance of doubt, the Amendment will not cause this registration statement to cover the offer and sale of any additional shares of the Registrant’s common stock that may be offered and sold under the 2018 Plan that were not previously issuable under the 2015 Plan. 

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PART II

INFORMATION REQUIRED IN REGISTRATION STATEMENT

Item 3.           INCORPORATION OF CERTAIN DOCUMENTS BY REFERENCE

The following documents filed with the Securities and Exchange Commission (the “Commission”) are hereby incorporated by reference into this Registration Statement:

(a) The Registrant’s Annual Report on Form 10-K for the year ended December 31, 2017, filed with the Commission on March 30, 2018, as amended by Form 10-K/A, filed with the Commission on May 22, 2018;

(b) The Registrant’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2018, filed with the Commission on May 15, 2018, as amended by Form 10-Q/A, filed with the Commission on May 22, 2018;

(c) The Registrant’s Current Report on Form 8-K, filed with the Commission on June 15, 2018; and

(d)          The description of the Registrant’s common stock contained in the Registration Statement on Form 8-A (File No. 001-37941) filed with the Commission on November 7, 2016 under the Securities Exchange Act of 1934, as amended (the “Exchange Act”); and any amendments or reports filed for the purpose of updating such description.

All documents the Registrant files pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Exchange Act after the date hereof, and prior to the filing of a post-effective amendment which indicates that the securities offered hereby have been sold or which deregisters all securities covered hereby then remaining unsold, shall also be deemed to be incorporated by reference into this Registration Statement and to be a part hereof commencing on the respective dates on which such documents are filed.

Item 4.   DESCRIPTION OF SECURITIES

Not applicable.

Item 5.   INTERESTS OF NAMED EXPERTS AND COUNSEL

None.

Item 6.   INDEMNIFICATION OF DIRECTORS AND OFFICERS

The Registrant incorporated under the laws of the State of Delaware. Section 145 of the Delaware General Corporation Law provides that a Delaware corporation may indemnify any persons who were, are, or are threatened to be made, parties to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative (other than an action by or in the right of such corporation), by reason of the fact that such person is or was an officer, director, employee or agent of such corporation, or is or was serving at the request of such corporation as an officer, director, employee or agent of another corporation, partnership, joint venture, trust or other enterprise. The indemnification may include expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably incurred by such person in connection with defending or settling such action, suit or proceeding, provided that such person acted in good faith and in a manner he or she reasonably believed to be in or not opposed to the corporation’s best interests except that no indemnification is permitted without judicial approval if the officer or director is adjudged to be liable to the corporation. Where an officer or director is successful on the merits or otherwise in the defense of any action referred to above, the corporation must indemnify him or her against the expenses (including attorneys’ fees) actually and reasonably incurred.

The Registrant’s amended and restated certificate of incorporation and amended and restated bylaws provide for the indemnification of its directors and officers to the fullest extent permitted under the Delaware General Corporation Law.

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Section 102(b)(7) of the Delaware General Corporation Law permits a corporation to provide in its certificate of incorporation that a director of the corporation shall not be personally liable to the corporation or its stockholders for monetary damages for breach of fiduciary duties as a director, except for liability for any:

● Breach of director’s duty of loyalty to the corporation or its stockholders.

● Act or omission not in good faith or that involves intentional misconduct or a knowing violation of law;

● Unlawful payment of dividends or unlawful purchase or redemption of shares; or

● Transaction from which the director derives an improper personal benefit;

The Registrant’s amended and restated certificate of incorporation includes such a provision. Expenses incurred by any officer or director in defending any such action, suit or proceeding in advance of its final disposition shall be paid by the Registrant upon delivery to it of an undertaking, by or on behalf of such director or officer, to repay all amounts so advanced if it shall ultimately be determined that such director or officer is not entitled to be indemnified by the Registrant.

Section 174 of the Delaware General Corporation Law provides, among other things, that a director who willfully or negligently approves of an unlawful payment of dividends or an unlawful stock purchase or redemption, may be held jointly and severally liable for such actions. A director who was either absent when the unlawful actions were approved or dissented at the time may avoid liability by causing his or her dissent to such actions to be entered in the books containing minutes of the meetings of the board of directors at the time such action occurred or immediately after such absent director receives notice of the unlawful acts.

As permitted by the Delaware General Corporation Law, the Registrant has entered into indemnification agreements with each of its directors and executive officers, that require the Registrant to indemnify such persons against any and all costs and expenses (including attorneys’, witness or other professional fees) actually and reasonably incurred by such persons in connection with any action, suit or proceeding (including derivative actions), whether actual or threatened, to which any such person may be made a party by reason of the fact that such person is or was a director or officer or is or was acting or serving as an officer, director, employee or agent of the Registrant or any of its affiliated enterprises. Under these agreements, the Registrant is not required to provide indemnification for certain matters, including:

● Indemnification for expenses or losses with respect to proceedings initiated by the director or officer, including any proceedings against the Registrant or its directors, officers, employees or other indemnitees and not by way of defense, with certain exceptions;

● Indemnification for any proceeding if a final decision by a court of competent jurisdiction determines that such indemnification is prohibited by applicable law;

● Indemnification for the disgorgement of profits arising from the purchase or sale by the director or officer of securities of the Registrant in violation of Section 16(b) of the Exchange Act, or any similar successor statute; or

● Indemnification for the director or officer’s reimbursement to the Registrant of any bonus or other incentive-based or equity-based compensation previously received by the director or officer or payment of any profits realized by the director or officer from the sale of securities of the Registrant, as required in each case under the Exchange Act.

The indemnification agreements also set forth certain procedures that will apply in the event of a claim for indemnification thereunder. The Registrant has an insurance policy in place, with limits of $20.0 million in the aggregate, that covers its officers and directors with respect to certain liabilities, including liabilities arising under the Securities Act or otherwise. Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the registrant pursuant to the foregoing provisions, or otherwise, the registrant has been advised that in the opinion of the SEC such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable

Item 7.    EXEMPTIONS FROM REGISTRATION CLAIMED

Not applicable.

Item 8.    EXHIBITS

Exhibit Number	Description
5.1	Opinion of Summit Law Group, PLLC regarding legality of the common stock being registered with respect to the SenesTech, Inc. 2009-2009 Non-Qualified Stock Option Plan and the SenesTech, Inc. 2015 Equity Incentive Plan (incorporated by reference to Exhibit 5.1 to the Registrant’s Registration Statement on Form S-8, filed on December 9, 2016 (File No. 333-215026))

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5.2	Opinion of Perkins Coie LLP regarding legality of the common stock being registered with respect to the SenesTech, Inc. 2018 Equity Incentive Plan.
23.1	Consent of M&K CPAS, PLLC
23.2	Consent of Perkins Coie LLP (included in opinion filed as Exhibit 5.2)
24.1	Power of Attorney (incorporated by reference to Exhibit 24.1 to the Registrant’s Registration Statement on Form S-8 (File No. 333-215026) filed with the SEC on December 9, 2016 )
99.1	SenesTech, Inc. 2008-2009 Non-Qualified Stock Option Plan (incorporated by reference to Exhibit 10.1 to the Registrant’s Registration Statement on Form S-1 (File No. 333-213736) filed with the SEC on September 21, 2016)
99.2	SenesTech, Inc. 2015 Equity Incentive Plan (incorporated by reference to Exhibit 10.2 to the Registrant’s Registration Statement on Form S-1 (File No. 333-213736) filed with the SEC on September 21, 2016)
99.3	SenesTech, Inc. 2018 Equity Incentive Plan (incorporated by reference to Annex A to the Registrant’s definitive proxy statement on Schedule 14A with respect to the 2018 annual meeting of stockholders filed with the SEC on April 30, 2018)

Item 9.   UNDERTAKINGS

A.           The undersigned Registrant hereby undertakes:

(1)          To file, during any period in which offers or sales are being made, a post-effective amendment to this Registration Statement:

(a)            To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933, as amended (the “Securities Act”);

(b)            To reflect in the prospectus any facts or events arising after the effective date of this Registration Statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in this Registration Statement; and

(c)            To include any material information with respect to the plan of distribution not previously disclosed in this Registration Statement or any material change to such information in this Registration Statement;

provided, however, that paragraphs (1)(a) and (1)(b) above do not apply if the information required to be included in a post-effective amendment by those paragraphs is contained in reports filed with or furnished to the Commission by the Registrant pursuant to Section 13 or 15(d) of the Exchange Act that are incorporated by reference in this Registration Statement.

(2)           That, for the purpose of determining any liability under the Securities Act, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

(3)           To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.

B.             The undersigned Registrant hereby undertakes that, for purposes of determining any liability under the Securities Act, each filing of the Registrant’s annual report pursuant to Section 13(a) or Section 15(d) of the Exchange Act (and, where applicable, each filing of an employee benefits plan’s annual report pursuant to Section 15(d) of the Exchange Act) that is incorporated by reference in this Registration Statement shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

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C.             Insofar as indemnification for liabilities arising under the Securities Act may be permitted to directors, officers and controlling persons of the Registrant pursuant to the foregoing provisions, or otherwise, the Registrant has been advised that, in the opinion of the Commission, such indemnification is against public policy as expressed in the Securities Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the Registrant of expenses incurred or paid by a director, officer or controlling person of the Registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the Registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Securities Act and will be governed by the final adjudication of such issue.

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SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the registrant certifies that it has reasonable grounds to believe that it meets all the requirements for filing on Form S-8 and has duly caused this Post-Effective Amendment No. 1 to the Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the City of Flagstaff, State of Arizona, on June 18, 2018.

SENESTECH, INC.
/s/ Thomas C. Chesterman
By:	Thomas C. Chesterman Chief Financial Officer

Pursuant to the requirements of the Securities Act of 1933, this Post-Effective Amendment No. 1 to the Registration Statement has been signed by the following persons in the capacities indicated below on June 18, 2018. 

Signature	Title
/s/ Loretta P. Mayer*	Chair of the Board, Chief Executive Officer and Chief Scientific Officer
Loretta P. Mayer	(Principal Executive Officer)
/s/ Thomas C. Chesterman	Chief Financial Officer and Treasurer
Thomas C. Chesterman	(Principal Financial and Accounting Officer)
	Director
Jamie Bechtel
	Director
Delphine François Chiavarini
/s/ Marc Dumont*	Director
Marc Dumont
/s/ Matthew K. Szot*	Director
Matthew K. Szot
/s/ Grover Wickersham*	Director
Grover Wickersham
/s/ Julia Williams*	Director
Julia Williams
/s/ Thomas C. Chesterman
*Thomas C. Chesterman, as attorney in fact

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