<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2021-05-26</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001680378</issuerCik>
        <issuerName>SenesTech, Inc.</issuerName>
        <issuerTradingSymbol>SNES</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001862241</rptOwnerCik>
            <rptOwnerName>Williams Nicole C</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O SENESTECH, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>23460 N. 19TH AVE, STE 110</rptOwnerStreet2>
            <rptOwnerCity>PHOENIX</rptOwnerCity>
            <rptOwnerState>AZ</rptOwnerState>
            <rptOwnerZipCode>85027</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>1</isOfficer>
            <officerTitle>Chief Strategy Officer</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable></nonDerivativeTable>

    <derivativeTable></derivativeTable>

    <footnotes></footnotes>

    <remarks>Exhibit 24 Power of Attorney filed herewith</remarks>

    <ownerSignature>
        <signatureName>/s/ Thomas C. Chesterman, Attorney-in-fact</signatureName>
        <signatureDate>2021-05-26</signatureDate>
    </ownerSignature>
</ownershipDocument>
