X0306 4 2017-11-02 0001680378 SenesTech, Inc. SNES 0001689556 Dyer Cheryl Ann C/O SENESTECH, INC. 3140 N. CADEN COURT, SUITE 1 FLAGSTAFF AZ 86004 1 1 Pres. & Chief Research Officer Common Stock 2017-10-10 5 G 0 40000.0000 0.0000 D 399201.0000 D Common Stock 2017-11-02 4 S 0 6000.0000 2.7232 D 393201.0000 D Common Stock 100000.0000 I 2016 Dyer Mayer Family Delaware Trust The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person July 5, 2017. The price shown is a weighted average sales price. The shares were sold at prices ranging from $2.76 to $2.80 per share. The reporting person will provide to the issuer, any security holder of the issuer, or the SEC staff, upon request, information regarding the number of shares sold at each price within the range. /s/ Kim Wolin as Attorney-in-Fact 2017-11-03