Common Stock Warrants and Common Stock Warrant Liability (Details) - USD ($) $ / shares in Units, $ in Thousands								1 Months Ended											12 Months Ended
	Oct. 26, 2020	Mar. 04, 2020	Mar. 03, 2020	Jan. 28, 2020	Aug. 13, 2018	Jul. 24, 2018	Nov. 21, 2017	Mar. 23, 2021	Feb. 28, 2021	Oct. 31, 2020	Oct. 26, 2020	Apr. 24, 2020	Mar. 31, 2020	Jan. 31, 2020	Jan. 28, 2020	Jul. 31, 2019	Jun. 30, 2018	Jun. 20, 2018	Dec. 31, 2021	Dec. 31, 2020	Mar. 06, 2020
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Expected volatility rate																			95.80%	92.10%
Expected term																			3 years 3 days	3 years 6 months
Expected dividend rate
Risk free interest rate																			0.46%	0.17%
Deemed dividend (in Dollars)																			$ 285
Unexercised warrants (in Shares)																			143,501
Share price																			$ 0.98	$ 1.73
Stock compensation expense (in Dollars)																			$ 765	$ 645
Common stock, par value																			$ 0.001	$ 0.001
Common stock sold (in Shares)									4,188,854
Warrant activity [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price		$ 2.1122			$ 19	$ 29.4													$ 30
Adjusted exercise price	$ 2.1122			$ 19
Downward exercise price	1.3659			7.13
Outstanding Warrants [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price							$ 30
Downward exercise price						$ 29.4
Common stock offering warrants issued, value (in Shares)																			4,531,447
Weighted-average exercise price																			$ 4
Common Stock Offering Warrants Issued [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price					19		$ 30										$ 36.4	$ 36.4
Common stock offering warrants issued, value (in Shares)							232,875
Number of warrant purchased (in Shares)																	56,696	56,696
Common stock per share							$ 20										$ 42.2
Warrant term							5 years
Fair value of common stock warrant (in Dollars)							$ 661
Per share price							$ 20
Expected volatility rate							73.80%								73.80%		72.60%
Expected term							5 years								2 years 9 months 25 days		5 years
Expected dividend rate							0.00%								0.00%		0.00%
Risk free interest rate							1.87%								1.45%		2.80%
Share price				7.9											$ 7.9
Stock compensation expense (in Dollars)																	$ 1,700
Fair value adjustment of warrants (in Dollars)																	$ 1,700
Common Stock Warrant Issued to Underwriter of Common Stock Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price				$ 7.13											$ 7.13
Common stock per share										$ 2.156
Expected volatility rate		74.50%									96.50%
Expected term		2 years 8 months 15 days									2 years 29 days
Expected dividend rate		0.00%									0.00%
Risk free interest rate		0.68%									0.18%
Deemed dividend (in Dollars)		$ 129									$ 22
Share price	$ 1.47	$ 2.88									$ 1.47
Warrants exercise price		$ 2.1122									$ 1.3659
Unexercised warrants (in Shares)		143,501									143,501
November 2017 warrants [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock offering warrants issued, value (in Shares)																		56,696
Number of warrant purchased (in Shares)																		56,696
Common stock per share																		$ 30
Gross proceeds (in Dollars)																		$ 1,700
New Warrants November 8, 2017 [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Number of warrant purchased (in Shares)																	17,088
Gross proceeds (in Dollars)																	$ 513
Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price					$ 23														$ 34.5
Common stock offering warrants issued, value (in Shares)					267,853														13,393
Common stock per share					$ 18.8														$ 18.8
Fair value of common stock warrant (in Dollars)					$ 3,600														$ 169
Expected volatility rate					159.00%														159.00%
Expected term					5 years														5 years
Expected dividend rate					0.00%														0.00%
Risk free interest rate					2.77%														2.77%
Share price					$ 23
Purchase of warrants shares (in Shares)					267,853
Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price																$ 33.75
Number of warrant purchased (in Shares)																8,334
Common stock per share																$ 33.75
Fair value of common stock warrant (in Dollars)																$ 127
Expected volatility rate																133.30%
Expected term																5 years
Expected dividend rate																0.00%
Risk free interest rate																2.07%
Share price																$ 26.8
Common Stock Warrants Issued in January and March 2020 Private Placements [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price													$ 2.88	$ 9
Common stock offering warrants issued, value (in Shares)														353,872
Number of warrant purchased (in Shares)													176,372	177,500
Expected volatility rate													74.80%	73.80%
Expected term													5 years 6 months	5 years
Expected dividend rate													0.00%	0.00%
Risk free interest rate													0.39%	1.53%
Common stock warrants, exercisable													$ 2.88	$ 9
Common stock warrants, exercisable amount (in Dollars)													$ 242	$ 813
Common stock price													$ 2.35	$ 7.9
Ownership percentage																			50.00%
Common Stock Warrants Issued in April 2020 Public Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price												$ 3.05
Number of warrant purchased (in Shares)												1,574,308
Expected volatility rate																			87.90%
Expected term																			5 years
Expected dividend rate																			0.00%
Risk free interest rate																			0.18%
Common stock warrants, exercisable																			$ 3,050.00
Common stock warrants, exercisable amount (in Dollars)																			$ 2,402
Common stock price																			$ 2.4
Warrant expire date												Apr. 24, 2025
Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price												$ 3.97	$ 2.35	$ 7.9					2.4
Common stock offering warrants issued, value (in Shares)													13,313	13,228
Common stock per share													$ 3.7563	$ 10					$ 3.97
Expected volatility rate													74.80%	73.80%					87.90%
Expected term													5 years 6 months	5 years					5 years 6 months
Expected dividend rate													0.00%	0.00%					0.00%
Risk free interest rate													0.39%	1.53%					0.18%
Common stock warrants, exercisable														$ 10
Common stock warrants, exercisable amount (in Dollars)													$ 17	$ 58					$ 167
Exercise outstanding warrants (in Shares)										1,700,680
Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Number of warrant purchased (in Shares)												118,073
Common Stock Warrants Issued to Placement Agent in October 2020 Inducement Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price										$ 1.725									$ 1.725
Adjusted exercise price																			3.05
Downward exercise price																			$ 2.88
Warrant term										5 years
Expected volatility rate																			96.50%
Expected term																			5 years 6 months
Expected dividend rate																			0.00%
Risk free interest rate																			0.18%
Share price																			$ 1.47
Purchase of warrants shares (in Shares)										1,700,680
Common stock warrants, exercisable																			$ 1.725
Common stock warrants, exercisable amount (in Dollars)																			$ 1,806
Common Stock Warrants Issued to Placement Agent in October 2020 Inducement Offering [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Purchase of warrants shares (in Shares)										85,034
Common Stock Warrants Issued to Placement Agent in October 2020 Inducement Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock per share										$ 1.47
Fair value of common stock warrant (in Dollars)										$ 86
Expected volatility rate										96.50%
Expected term										5 years 6 months
Expected dividend rate										0.00%
Risk free interest rate										0.18%
Fair value adjustment of warrants (in Dollars)																			$ 237
Purchase of warrants shares (in Shares)																			1,700,680
Common Stock Warrants Issued to Placement Agent in October 2020 Inducement Offering [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price										$ 2.156
Common Stock Warrants Issued in February 2021 Private Placement Agreement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price									$ 2.216										$ 2.216
Common stock per share																			$ 1.93
Expected volatility rate																			95.60%
Expected term																			5 years 6 months
Expected dividend rate																			0.00%
Risk free interest rate																			0.18%
Fair value adjustment of warrants (in Dollars)																			$ 3,052
Purchase of warrants shares (in Shares)									2,194,427
Common Stock Warrants Issued in February 2021 Private Placement Agreement [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price									$ 2.8481
Common Stock Warrants Issued to Placement Agent in February 2021 Private Placement Agreement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price																			$ 2.8481
Common stock per share																			$ 1.93
Expected volatility rate																			95.60%
Expected term																			5 years 6 months
Expected dividend rate																			0.00%
Risk free interest rate																			0.18%
Fair value adjustment of warrants (in Dollars)																			$ 435
Common Stock Warrants Issued to Placement Agent in February 2021 Private Placement Agreement [Member] | H.C. Wainwright & Co., LLC [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Purchase of warrants shares (in Shares)									329,164
Common Stock Warrants Issued to Placement Agent in March 2021 Registered Direct Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price																			$ 2.5
Common stock offering warrants issued, value (in Shares)								1,975,000
Warrant term																			5 years
Per share price																			$ 2.5
Expected volatility rate																			100.80%
Expected term																			5 years
Expected dividend rate																			0.00%
Risk free interest rate																			0.31%
Share price								$ 2											$ 1.76
Stock compensation expense (in Dollars)																			$ 181
Purchase of warrants shares (in Shares)																			148,125
Common stock, par value								$ 0.001
Deducting fees payable (in Dollars)								$ 3,950
Common stock sold (in Shares)								1,975,000
Deemed Dividend Adjustment-Warrant Modified Terms Revaluation [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price												$ 1.725
Common stock offering warrants issued, value (in Shares)			56,625
Common stock per share																			$ 1.47
Expected volatility rate																			96.50%
Expected dividend rate																			0.00%
Risk free interest rate																			0.18%
Exercise outstanding warrants (in Shares)											1,700,680
Aggregate issued common shares (in Shares)			51,414
Outstanding litigation reserve (in Dollars)			$ 238
Deemed Dividend Adjustment-Warrant Modified Terms Revaluation [Member] | Minimum [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price																					$ 2.88
Expected term																			4 years 6 months
Deemed Dividend Adjustment-Warrant Modified Terms Revaluation [Member] | Maximum [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Exercise price																					$ 3.05
Expected term																			8 years
Public Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Number of warrant purchased (in Shares)							293,000
Common Class A [Member] | Common Stock Warrants Issued in April 2020 Public Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock offering warrants issued, value (in Shares)												145,586
Common Class A [Member] | Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock offering warrants issued, value (in Shares)												145,586
Common Class B [Member] | Common Stock Warrants Issued in April 2020 Public Offering [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock offering warrants issued, value (in Shares)												1,428,722
Common Class B [Member] | Common Stock Warrants Issued to Placement Agent in 2020 Registered Direct Offerings and Private Placement [Member]
Common Stock Warrants and Common Stock Warrant Liability (Details) [Line Items]
Common stock offering warrants issued, value (in Shares)												1,428,722