Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2021

Share-based Payment Arrangement [Abstract]

Schedule of fair value of options granted

	Employee
Expected volatility		95.8	%
Expected dividend yield		-
Expected term (in years)		3.01
Risk-free interest rate		0.46	%

	Employee
Expected volatility		92.1	%
Expected dividend yield		-
Expected term (in years)		3.5
Risk-free interest rate		0.17	%

Schedule of stock option activity

	Number of Options			Weighted Average Exercise Price Per Share		Weighted Average Remaining Contractual Term (years)		Aggregate Intrinsic Value (1)
Outstanding at December 31, 2019		136,489		$	27.85		3.9	$	-
Granted		370,397		$	1.37		4.9	$	-
Exercised		-		$	-		-	$	-
Forfeited		(10,415	)	$	-		-	$	-
Expired		-		$	-		-	$	-
Outstanding at December 31, 2020		496,471		$	8.63		3.9	$	-
Granted		598,649		$	0.97		4.6	$	-
Exercised		-		$	-		-	$	-
Forfeited		(3,300	)	$	-		-	$	-
Expired		(4,000	)	$	-		-	$	-
Outstanding at December 31, 2021		1,087,820		$	4.08		3.9	$	-
Exercisable at December 31, 2021		649,153		$	5.38		1.8	$	-

(1) The aggregate intrinsic value on the table was calculated based on the difference between the estimated fair value of our stock and the exercise price of the underlying option. The estimated stock values used in the calculation was $0.98 and $1.73 per share for each of the years ended December 31, 2021 and 2020, respectively.

Schedule of summarizes restricted stock unit activity

	Number of Units			Weighted Average Grant Date Fair Value Per Unit
Outstanding as of December 31, 2019		5,877		$	30.28
Granted		30,738	(1)	$	1.97
Vested		(4,543	)	$	1.42
Forfeited		-		$	-
Outstanding as of December 31, 2020		32,072		$	4.13
Granted		-		$	-
Vested		(31,405	)	$	4.22
Forfeited		-		$	-
Outstanding as of December 31, 2021		667		$	1.80

(1) 30,738 restricted stock units were granted on July 23, 2020 with a weighted average grant date fair value of $1.97.

Schedule of stock-based compensation expense

	Years Ended December 31,
	2021		2020
Research and development	$	3	$	9
General and administrative		762		636
Total stock-based compensation expense	$	765	$	645