September 22, 2016

The Secretary

Securities and Exchange Commission

100 F Street, N.E.

Washington, D.C. 20549-9303

Attn.:	Ms. Anne Nguyen Parker Assistant Director
	Office of Transportation and Leisure

Re:	SenesTech, Inc.
	Draft Registration Statement on Form S-1
	Submitted August 3, 2016
	CIK No. 0001680378

Dear Ms. Parker:

On behalf of SenesTech, Inc. (the “Company”), as a follow up to our letter submitted to you dated September 21, 2016, and in accordance with our phone call with Don Field held on September 22, 2016, we submit this letter to you as an additional response to comment No. 1 of the Staff (the “Staff”) of the Securities and Exchange Commission (the “Commission”) regarding the above-referenced filing, which comments were received by the Company in a letter from the Staff dated August 30, 2016. Specifically, enclosed with this letter please find mock-ups of the cover artwork to be presented in the preliminary prospectus.

Please direct all correspondence, notices and orders issued with respect to this matter to the undersigned. If you would like to discuss this matter by telephone, my direct line is (206) 676-7118.

Sincerely,

Summit Law Group, PLLC

a professional limited liability company

/s/ Andrew W. Shawber

Andrew W. Shawber

cc:	Loretta P. Mayer and Thomas C. Chesterman (SenesTech, Inc.)
	Laura A. Bertin

Enclosures.