May 7, 2025

Joel L. Fruendt
President and Chief Executive Officer
SenesTech, Inc.
13430 North Dysart Road, Suite 105
Surprise, Arizona 85379

        Re: SenesTech, Inc.
            Registration Statement on Form S-3
            Filed May 2, 2025
            File No. 333-286955
Dear Joel L. Fruendt:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Margaret Sawicki at 202-551-7153 with any questions.



                                                           Sincerely,

                                                           Division of
Corporation Finance
                                                           Office of Industrial
Applications and
                                                           Services
cc:   Katherine A. Beck, Esq.