United States securities and exchange commission logo





                           October 31, 2022

       Kenneth Siegel
       Chief Executive Officer
       SenesTech, Inc.
       23460 N 19th Ave., Suite 110
       Phoenix, Arizona 85027

                                                        Re: SenesTech, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed October 24,
2022
                                                            File No. 333-267991

       Dear Kenneth Siegel:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Jane
Park at 202-551-7439 with any questions.




                           Sincerely,


                           Division of Corporation Finance

                           Office of Industrial Applications and

                           Services
       cc:                                              Katherine Beck, Esq.