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                          December 11, 2020

       Kenneth Siegel
       Chief Executive Officer
       SenesTech, Inc.
       23460 N 19th Ave., Suite 110
       Phoenix, AZ 85027

                                                        Re: SenesTech, Inc.
                                                            Registration
Statement on Form S-1
                                                            Filed December 7,
2020
                                                            File No. 333-251173

       Dear Mr. Siegel:

              This is to advise you that we have not reviewed and will not
review your registration
       statement.

               Please refer to Rules 460 and 461 regarding requests for
acceleration. We remind you
       that the company and its management are responsible for the accuracy and
adequacy of their
       disclosures, notwithstanding any review, comments, action or absence of
action by the staff.

                                                        Please contact Chris
Edwards at 202-551-6761 with any questions.




                          Sincerely,


                          Division of Corporation Finance

                          Office of Life Sciences
       cc:                                              Kara Tatman