February 11, 2020

Tom Chesterman
Chief Financial Officer
SenesTech, Inc.
23460 N 19th Ave., Suite 110
Phoenix, AZ 85027

       Re: SenesTech, Inc.
           Registration Statement on Form S-1
           Filed February 7, 2020
           File No. 333-236302

Dear Mr. Chesterman:

       This is to advise you that we have not reviewed and will not review your
registration
statement.

        Please refer to Rules 460 and 461 regarding requests for acceleration.
We remind you
that the company and its management are responsible for the accuracy and
adequacy of their
disclosures, notwithstanding any review, comments, action or absence of action
by the staff.

       Please contact Courtney Lindsay at (202) 551-7237 with any questions.



                                                            Sincerely,

                                                            Division of
Corporation Finance
                                                            Office of Life
Sciences
cc:    Kara Tatman