<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2024-11-08</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001679628</issuerCik>
        <issuerName>JUPITER NEUROSCIENCES, INC.</issuerName>
        <issuerTradingSymbol>JUNS</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001877774</rptOwnerCik>
            <rptOwnerName>Elmasri Saleem</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O JUPITER NEUROSCIENCES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1001 NORTH US HWY 1, SUITE 504</rptOwnerStreet2>
            <rptOwnerCity>JUPITER</rptOwnerCity>
            <rptOwnerState>FL</rptOwnerState>
            <rptOwnerZipCode>33477</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>0</isDirector>
            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
            <officerTitle>CFO and Secretary</officerTitle>
            <otherText></otherText>
        </reportingOwnerRelationship>
    </reportingOwner>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Stock option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.33</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2023-01-01</value>
            </exerciseDate>
            <expirationDate>
                <value>2032-12-31</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>562500</value>
                    <footnoteId id="F1"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.33</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2023-09-29</value>
            </exerciseDate>
            <expirationDate>
                <value>2033-09-28</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>81600</value>
                    <footnoteId id="F2"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Stock option (right to buy)</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>1.33</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2023-12-18</value>
            </exerciseDate>
            <expirationDate>
                <value>2033-12-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>22320</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Restricted stock unit</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <value>2023-12-18</value>
            </exerciseDate>
            <expirationDate>
                <value>2033-12-17</value>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>66293</value>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Fully vested stock options which were granted on January 1, 2023 pursuant to the approval of the board of directors of the issuer.</footnote>
        <footnote id="F2">Fully vested stock options which were granted on September 29, 2023 pursuant to the approval of the board of directors of the issuer as partial consideration for forgiveness of earned compensation owed by the issuer to the Reporting Person.</footnote>
        <footnote id="F3">Fully vested stock options which were granted on December 18, 2023 pursuant to the approval of the board of directors of the issuer as partial consideration for forgiveness of earned compensation owed by the issuer to the Reporting Person.</footnote>
        <footnote id="F4">Restricted stock units which were granted on December 18, 2023 under the Company's 2023 Equity Incentive Plan as partial consideration for forgiveness of earned compensation owed by the issuer to the Reporting Person. The restricted stock units vest at 100% 180 days after the first day of trading of an IPO.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>/s/ Saleem Elmasri</signatureName>
        <signatureDate>2024-11-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
