X0508 4 2023-09-07 0 0001679363 Morphic Holding, Inc. MORF 0001773184 SCHEGERIN MARC C/O MORPHIC HOLDING, INC. 35 GATEHOUSE DRIVE, A2 WALTHAM MA 02451 0 1 0 0 CFO and COO 0 Common Stock 2023-09-07 4 M 0 20000 15.00 A 44136 D Common Stock 2023-09-07 4 S 0 6691 53.2004 D 37445 D Common Stock 2023-09-07 4 S 0 13309 54.9166 D 24136 D Stock Option (right to buy Common Stock) 15.00 2023-09-07 4 M 0 20000 0.00 D 2030-04-05 Common Stock 20000 57268 D Includes 396 shares of Common Stock acquired under the Issuer's employee stock purchase plan on February 28, 2022. The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person dated June 28, 2022. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $53.00 to $53.73 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $54.19 to $55.10 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option vested as to 25% of the total shares on April 6, 2021, and then 1/48 of the total shares vest monthly thereafter, with 100% of the total shares vested and exercisable on April 6, 2024, subject to the reporting person's provision of service to the Issuer on each vesting date. /s/ Robert Farrell as attorney-in-fact for Marc Schegerin 2023-09-08