X0407 4 2023-05-03 0 0001679363 Morphic Holding, Inc. MORF 0001779978 Tipirneni Praveen P. C/O MORPHIC HOLDING, INC. 35 GATEHOUSE DRIVE, A2 WALTHAM MA 02451 1 1 0 0 President and CEO 0 Common Stock 2023-05-03 4 M 0 3597 4.32 A 17533 D Common Stock 2023-05-03 4 S 0 3597 51.114 D 13936 D Stock Option (right to buy Common Stock) 4.32 2023-05-03 4 M 0 3597 0.00 D 2028-12-14 Common Stock 3597 372774 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the holder dated September 16, 2022. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $51.00 to $51.33 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. This option is fully vested. /s/ Robert Farrell as attorney-in-fact for Praveen P. Tipirneni 2023-05-05