X0306 4 2021-06-10 0 0001679363 Morphic Holding, Inc. MORF 0001592280 Farrell Robert E Jr C/O MORPHIC HOLDING, INC. 35 GATEHOUSE DRIVE, A2 WALTHAM MA 02451 0 1 0 0 SVP Finance and CAO Common Stock 2021-06-10 4 M 0 16000 4.32 A 33934 D Common Stock 2021-06-10 4 S 0 16000 60.0762 D 17934 D Common Stock 2021-06-14 4 M 0 3526 4.32 A 21460 D Common Stock 2021-06-14 4 S 0 3526 65.0028 D 17934 D Stock Option (right to buy Common Stock) 4.32 2021-06-10 4 M 0 16000 0.00 D 2028-12-14 Common Stock 16000 79270 D Stock Option (right to buy Common Stock) 4.32 2021-06-14 4 M 0 3526 0.00 D 2028-12-14 Common Stock 3526 75744 D The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $60.00 to $60.325 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The reported price in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $65.00 to $65.02 per share, inclusive. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The option vests as to 2.0833% of the total shares monthly, beginning January 14, 2019, with 100% of the total shares vested and exercisable on December 14, 2022, subject to the reporting person's provision of service to the issuer on each vesting date. /s/ Robert Farrell, Jr. 2021-06-14