X0306 4 2021-04-21 0 0001679363 Morphic Holding, Inc. MORF 0001641354 Omega Fund V, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 1 0 0 0 0001641355 Omega Fund V GP, L.P. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 1 0 0 0 0001641348 Omega Fund V GP Manager, Ltd. 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 1 0 0 0 0001361712 Stampacchia Otello 888 BOYLSTON STREET, SUITE 1111 BOSTON MA 02199 1 0 0 0 Common Stock 2021-04-21 4 S 0 1929 53.76 D 2128451 D Common Stock 2021-04-21 4 S 0 109 55.15 D 2128342 D Common Stock 2021-04-21 4 S 0 1991 56.74 D 2126351 D Common Stock 2021-04-21 4 S 0 3523 57.48 D 2122828 D Common Stock 2021-04-22 4 S 0 2577 56.34 D 2120251 D Common Stock 2021-04-22 4 S 0 5329 57.08 D 2114922 D Common Stock 2021-04-22 4 S 0 1640 57.88 D 2113282 D Common Stock 2021-04-22 4 S 0 2326 59.37 D 2110956 D Common Stock 2021-04-22 4 S 0 363 59.75 D 2110593 D Shares were sold pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $53.37 to $54.27 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.18 to $57.16 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.18 to $57.99 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $55.69 to $56.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $56.69 to $57.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $57.68 to $58.56 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $58.68 to $59.67 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions at prices ranging from $59.70 to $59.78 inclusive. The reporting person hereby undertakes to provide upon request to the SEC staff, the issuer or a security holder of the issuer full information regarding the number of shares and prices at which the transaction was effected. The reported securities are held directly by Omega Fund V, L.P. ("Omega V"). The reported securities may be deemed to be beneficially owned by each of Omega Fund V GP, L.P. ("Omega V GP"), as the general partner of Omega V, and Omega Fund V GP Manager, Ltd. ("Omega V GP Manager"), as the general partner of Omega V GP. Otello Stampacchia, Anne-Mari Paster and Claudio Nessi (the "Omega Directors") are all the shareholders and directors of Omega V GP Manager and have shared voting and investment power over the shares held by Omega V. Each of Omega V GP, Omega Fund V GP Manager and the Omega Directors disclaims beneficial ownership of the securities reported herein, except to the extent of its or their pecuniary interest therein, if any. Otello Stampacchia is a director of the issuer. /s/ Anne-Mari Paster, as an authorized signatory of each Reporting Person 2021-04-23