2105100 - Disclosure - Accrued Expenses
link:presentationLink
link:calculationLink
link:definitionLink
2405402 - Disclosure - Accrued Expenses - Schedule of Accrued Expenses (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2305301 - Disclosure - Accrued Expenses (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2128100 - Disclosure - Commitments and Contingencies
link:presentationLink
link:calculationLink
link:definitionLink
1002000 - Statement - Consolidated Balance Sheets
link:presentationLink
link:calculationLink
link:definitionLink
1002501 - Statement - Consolidated Balance Sheets (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
1006000 - Statement - Consolidated Statement of Cash Flows
link:presentationLink
link:calculationLink
link:definitionLink
1004000 - Statement - Consolidated Statements of Comprehensive Loss
link:presentationLink
link:calculationLink
link:definitionLink
1003000 - Statement - Consolidated Statements of Operations
link:presentationLink
link:calculationLink
link:definitionLink
1003001 - Statement - Consolidated Statements of Operations (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
1005000 - Statement - Consolidated Statements of Shareholders' Equity (Deficit)
link:presentationLink
link:calculationLink
link:definitionLink
1005001 - Statement - Consolidated Statements of Shareholders' Equity (Deficit) (Parenthetical)
link:presentationLink
link:calculationLink
link:definitionLink
2122100 - Disclosure - Defined Contribution Plan
link:presentationLink
link:calculationLink
link:definitionLink
2422401 - Disclosure - Defined Contribution Plan - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2101100 - Disclosure - Description of Business
link:presentationLink
link:calculationLink
link:definitionLink
2401401 - Disclosure - Description of Business - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2126100 - Disclosure - Development and Commercialization Agreement
link:presentationLink
link:calculationLink
link:definitionLink
2426401 - Disclosure - Development and Commercialization Agreement (Details)
link:presentationLink
link:calculationLink
link:definitionLink
0001000 - Document - Document and Entity Information
link:presentationLink
link:calculationLink
link:definitionLink
2106100 - Disclosure - Financing Arrangements
link:presentationLink
link:calculationLink
link:definitionLink
2406402 - Disclosure - Financing Arrangements - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2406403 - Disclosure - Financing Arrangements - Outstanding Debt Obligations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2406403 - Disclosure - Financing Arrangements - Outstanding Debt Obligations (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2306301 - Disclosure - Financing Arrangements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2116100 - Disclosure - Income Taxes
link:presentationLink
link:calculationLink
link:definitionLink
2416405 - Disclosure - Income Taxes - Deferred Taxes (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2416403 - Disclosure - Income Taxes - Effective Income Tax Reconciliation (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2416402 - Disclosure - Income Taxes - Loss Before Income Taxes and Related Tax Benefit (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2416404 - Disclosure - Income Taxes - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2316301 - Disclosure - Income Taxes (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2416406 - Disclosure - Income Taxes - Unrecognized Tax Benefit (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2103100 - Disclosure - Investments and Fair Value Measurements
link:presentationLink
link:calculationLink
link:definitionLink
2403403 - Disclosure - Investments and Fair Value Measurements - Assets and Liabilities Measured at Fair Value on a Recurring Basis (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2403402 - Disclosure - Investments and Fair Value Measurements - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2303301 - Disclosure - Investments and Fair Value Measurements (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2125100 - Disclosure - Leases
link:presentationLink
link:calculationLink
link:definitionLink
2425402 - Disclosure - Leases - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2425403 - Disclosure - Leases - Operating Lease Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2425405 - Disclosure - Leases - Operating Lease Liability Maturities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2425405 - Disclosure - Leases - Operating Lease Liability Maturities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2425404 - Disclosure - Leases - Operating Lease Right of Use Assets and Liabilities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2325301 - Disclosure - Leases (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2107100 - Disclosure - Related Party Transactions
link:presentationLink
link:calculationLink
link:definitionLink
2407401 - Disclosure - Related Party Transactions - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2129100 - Disclosure - Selected Quarterly Financial Data (Unaudited)
link:presentationLink
link:calculationLink
link:definitionLink
2429402 - Disclosure - Selected Quarterly Financial Data (Unaudited) - Schedule of Quarterly Data (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2329301 - Disclosure - Selected Quarterly Financial Data (Unaudited) (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2119100 - Disclosure - Share-Based Compensation
link:presentationLink
link:calculationLink
link:definitionLink
2419405 - Disclosure - Share-Based Compensation - Additional Information for Stock Options (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2419402 - Disclosure - Share-Based Compensation - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2419406 - Disclosure - Share-Based Compensation - Restricted Share Awards and Restricted Stock Units Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2419403 - Disclosure - Share-Based Compensation - Schedule of Fair Value Assumptions for Stock Options (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2419407 - Disclosure - Share-Based Compensation - Share-based Compensation Expense (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2419404 - Disclosure - Share-Based Compensation - Summary of Option Activity (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2319301 - Disclosure - Share-Based Compensation (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2108100 - Disclosure - Shareholders' (Deficit) Equity
link:presentationLink
link:calculationLink
link:definitionLink
2408401 - Disclosure - Shareholders' (Deficit) Equity - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2130100 - Disclosure - Subsequent Events
link:presentationLink
link:calculationLink
link:definitionLink
2430401 - Disclosure - Subsequent Events (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2102100 - Disclosure - Summary of Significant Accounting Policies
link:presentationLink
link:calculationLink
link:definitionLink
2402404 - Disclosure - Summary of Significant Accounting Policies - Cash, Cash Equivalents, and Restricted Cash (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2402403 - Disclosure - Summary of Significant Accounting Policies - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2202201 - Disclosure - Summary of Significant Accounting Policies (Policies)
link:presentationLink
link:calculationLink
link:definitionLink
2402405 - Disclosure - Summary of Significant Accounting Policies - Schedule of Antidilutive Securities (Details)
link:presentationLink
link:calculationLink
link:definitionLink
2302302 - Disclosure - Summary of Significant Accounting Policies (Tables)
link:presentationLink
link:calculationLink
link:definitionLink
2104100 - Disclosure - Takeda Agreements
link:presentationLink
link:calculationLink
link:definitionLink
2404401 - Disclosure - Takeda Agreements - Narrative (Details)
link:presentationLink
link:calculationLink
link:definitionLink