X0306 4 2019-07-05 0 0001631574 Wave Life Sciences Ltd. WVE 0001679039 Panzara Michael A. C/O WAVE LIFE SCIENCES LTD., 733 CONCORD AVE. CAMBRIDGE MA 02138 0 1 0 0 Chief Medical Officer Ordinary Shares 2019-07-05 4 S 0 2613 26.88 D 42775 D Ordinary Shares 2019-07-05 4 S 0 445 27.26 D 42330 D Consists of sale of restricted share units (RSUs) effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on May 17, 2019. The price reflected is the weighted-average sale price for shares sold. The shares were sold in multiple transactions and the range of sale prices for the transactions reported was $26.25 to $27.21 per share. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price. /s/ Michael A. Panzara 2019-07-09