X0508 4 2025-03-25 false 0001678660 Prelude Therapeutics Inc PRLD 0001825005 Combs Andrew C/O PRELUDE THERAPEUTICS INCORPORATED 175 INNOVATION BOULEVARD WILMINGTON DE 19805 false true false false Chief Chemistry Officer false Common Stock 2025-03-25 4 P false 100000.00 0.6925 A 480123.00 D The reported total includes 2,500 shares of common stock the reporting person has acquired since the date of his last ownership report through the issuer's Employee Stock Purchase Plan in one or more transactions exempt pursuant to Rules 16b-3(c). /s/ Krishna Vaddi, Attorney-in-Fact 2025-03-27