X0306 4 2022-06-17 false 0001678660 Prelude Therapeutics Inc PRLD 0001572451 Bonita David P C/O PRELUDE THERAPEUTICS INCORPORATED 200 POWDER MILL ROAD WILMINGTON DE 19803 true false true false Director Stock Option (Right to Buy) 4.74 2022-06-17 4 A false 34300.00 0.00 A 2032-06-16 Common Stock 34300.00 34300.00 D The option award will fully vest upon the earlier of (a) the Issuer's next annual stockholder meeting, or (b) the one-year anniversary of the grant date, such to the Reporting Person's provision of service to the Issuer on each vesting date. Pursuant to an agreement with OrbiMed Advisors LLC and OrbiMed Capital GP VI LLC, the Reporting Person is obligated to transfer any securities issued under any such stock options or other awards, or the economic benefit thereof, to OrbiMed Advisors LLC and OrbiMed Capital GP VI LLC, which will in turn ensure that such securities or economic benefits are provided to OrbiMed Private Investments VI, LP. /s/ Laurent Chardonnet, Attorney-in-Fact 2022-06-22