X0206 3 2020-09-24 0 0001678660 Prelude Therapeutics Inc PRLD 0001620368 Sandor Victor C/O PRELUDE THERAPEUTICS INCORPORATED 200 POWDER MILL ROAD WILMINGTON DE 19801 1 0 0 0 Director Stock Option (right to buy) 1.89 2030-05-12 Common Stock 43230 D The stock option fully vests with 100% of the total shares vested and exercisable on May 13, 2021, subject to the Reporting Person's provision of service to the Issuer on the vesting date. /s/ Brian Piper, as Attorney-in-Fact for Victor Sandor 2020-09-24