Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Income Tax Disclosure [Line Items]
Deferred tax assets, valuation allowance increase	$ 35,000,000	$ 36,600,000
Research and development tax credits	23,668,000	20,555,000
Deferred tax assets, capitalized research and development expense	$ 59,341,000	$ 39,867,000
NOL and tax credit carryforwards	The NOL and tax credit carryforwards are subject to review and possible adjustment by the Internal Revenue Service and state tax authorities. NOL and tax credit carryforwards may become subject to an annual limitation in the event of certain cumulative changes in the ownership interest of significant stockholders over a three year period in excess of 50%, as defined under Sections 382 and 383 of the Internal Revenue Code, respectively, as well as similar state provisions.
Accrued interest related to uncertain tax positions	$ 0
Accrued penalties related to uncertain tax positions	0
Interest related to uncertain tax positions	0
Penalties related to uncertain tax positions	$ 0
Non-U.S. Based
Income Tax Disclosure [Line Items]
Taxpayers required period to capitalize and amortize research development expense	15 years
U.S. Based
Income Tax Disclosure [Line Items]
Taxpayers required period to capitalize and amortize research development expense	5 years
Tennessee
Income Tax Disclosure [Line Items]
NOL carryforwards expiration year	2037
Massachusetts
Income Tax Disclosure [Line Items]
NOL carryforwards expiration year	2042
Internal Revenue Service (IRS)
Income Tax Disclosure [Line Items]
Research and development tax credits	$ 23,600,000
Tax credits expiration year	2039
Delaware
Income Tax Disclosure [Line Items]
Research and development tax credits	$ 43,000
Tax credits expiration year	2031