Segments - Schedule of Significant Expense Categories Reviewed by CODM (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023
Segment Reporting Information [Line Items]
Revenue from license agreement	$ 7,000
Operating expenses:
Research and development	117,995	$ 103,393
General and administrative	28,719	28,884
Total operating expenses	146,714	132,277
Loss from operations	(139,714)	(132,277)
Other income, net	12,541	10,445
Net loss	(127,173)	(121,832)
PRT3789
Operating expenses:
Research and development	20,173	9,738
PRT2527
Operating expenses:
Research and development	11,594	7,573
PRT7732
Operating expenses:
Research and development	9,195
Discovery Programs
Operating expenses:
Research and development	13,856	12,387
Other
Operating expenses:
Research and development	1,346	12,922
General Costs, Including Personnel Related
Operating expenses:
Research and development	$ 61,831	$ 60,773