Commitments - Additional Information (Details) $ in Thousands	1 Months Ended	3 Months Ended	12 Months Ended
	May 31, 2024 USD ($)	Sep. 30, 2022 USD ($)	Dec. 31, 2024 USD ($) ft² Extension	Dec. 31, 2023 USD ($)
Other Commitments [Line Items]
Right-of-use asset			$ 28,699	$ 30,412
Lease liability			17,817
Lease cost			4,400	2,500
Short-term lease cost			200	200
Cash paid in the measurement of operating lease liabilities			1,583	1,928
Reimbursements for development of lab space			$ 2,400
Reimbursements for development of lab space period			3 years
Reimbursements for development of lab space previous expiration year			2023
Reimbursements for development of lab space expiration year			2026
Additional grant for development of lab space		$ 1,000
Grant for development of lab space			$ 3,400
Disbursement incurred costs for lab space			3,400
Other income related to grant			$ 200
Defined contribution plan, maximum annual contributions per employee, percent			100.00%
Defined contribution plan, employer matching contribution, percent of employee's gross pay			3.00%
Defined contribution plan, employer discretionary contribution amount			$ 800	700
Research and development			117,995	103,393
Maximum
Other Commitments [Line Items]
Approved grant receivable to increasing jobs			3,100
License Agreement
Other Commitments [Line Items]
Transaction price	$ 3,000
Deferred revenue recognized			$ 7,000
Upfront, non-refundable fee	3,000
Near term payment upon transfer of materials	4,000
License Agreement | Maximum
Other Commitments [Line Items]
Potential developmental milestones receivable	37,000
Potential sales milestone	100,000
API Transfer
Other Commitments [Line Items]
Transaction price	$ 4,000
Chestnut Run Lease
Other Commitments [Line Items]
Lease renewal period			5 years
Operating lease estimated incremental borrowing rate percent			15.00%
Area of lease premises | ft²			81,000
Initial term of lease			162 months
Number of lease extensions | Extension			3
Chestnut Run Lease | Letter of Credit
Other Commitments [Line Items]
Security deposit			$ 4,000	$ 4,000
Chestnut Run Lease | Letter of Credit | Pro Forma
Other Commitments [Line Items]
Security deposit			$ 500