Segments (Tables)

12 Months Ended

Dec. 31, 2024

Segment Reporting [Abstract]

Schedule of Significant Expense Categories Reviewed by CODM

The following tables summarizes the significant expense categories regularly reviewed by the CODM for the years ended December 31, 2024, and 2023:

	Year ended December 31,
(in thousands)	2024			2023
Revenue from license agreement	$	7,000		$	—
Operating expenses:
Research and development
PRT3789	$	20,173		$	9,738
PRT2527		11,594			7,573
PRT7732		9,195			—
Discovery programs		13,856			12,387
Other		1,346			12,922
General costs, including personnel related		61,831			60,773
Total research and development		117,995			103,393
General and administrative		28,719			28,884
Total operating expenses	$	146,714		$	132,277
Loss from operations		(139,714	)		(132,277	)
Other income, net		12,541			10,445
Net loss	$	(127,173	)	$	(121,832	)