X0609 4 2026-05-05 0000318154 AMGEN INC AMGN 0001677950 Santos Esteban false ONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799 1 EVP, Operations 0 Common Stock 2026-05-05 4 A 0 2730 0 A 83796 D Common Stock 2026-05-06 4 F 0 427 329.59 D 83369 D Common Stock 909.9906 I 401K Plan Nqso (Right to Buy) 329.59 2026-05-05 4 A 0 17814 329.59 A 2027-05-05 2036-05-05 Common Stock 17814 17814 D The Restricted Stock Units (RSUs) were granted pursuant to the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan (the Equity Incentive Plan) and vest in four equal annual installments of 25% each, commencing on 5/5/2027. Vested RSUs will be paid in shares of the Company's common stock on a one-to-one basis. These shares include 388 Dividend Equivalents (DEs) granted pursuant to the Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited to the reporting person's unvested Restricted Stock Units and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount. These non-qualified stock options were granted pursuant to the Equity Incentive Plan and vest and are exercisable in four equal annual installments of 25% each, commencing on 5/5/2027. /s/ Esteban Santos 2026-05-06