X0508 4 2026-02-26 0000318154 AMGEN INC AMGN 0001677950 Santos Esteban ONE AMGEN CENTER DRIVE THOUSAND OAKS CA 91320-1799 1 EVP, Operations 0 Common Stock 2026-02-26 4 M 0 30501 162.60 A 107119 D Common Stock 2026-02-26 4 S 0 30501 379.1173 D 76618 D Common Stock 2026-02-26 4 M 0 24291 177.46 A 100909 D Common Stock 2026-02-26 4 S 0 24291 379.1173 D 76618 D Common Stock 903.8036 I 401K Plan Nqso (Right to Buy) 162.60 2026-02-26 4 M 0 30501 0 D 2019-05-01 2027-05-01 Common Stock 30501 0 D Nqso (Right to Buy) 177.46 2026-02-26 4 M 0 24291 0 D 2020-04-27 2028-04-27 Common Stock 24291 0 D Includes shares sold to cover the option exercise price and required withholding taxes in connection with the exercise of expiring options. The price reported is an average price of $379.1173 per share. Full information regarding the number of shares purchased at each separate price within the range is available upon request by the SEC staff, the issuer or a security holder of the issuer These shares include 624 Dividend Equivalents (DEs) granted pursuant to the Amgen Inc. Second Amended and Restated 2009 Equity Incentive Plan and subject to a qualifying dividend reinvestment plan. DEs are credited to the reporting person's unvested RSUs and are paid out in shares of the Company's common stock on a one-to-one basis according to the vesting schedule, along with a cash payment for any remaining fractional share amount. These shares are acquired under the Company's 401(k) Plan and represent interests in the Company's stock fund as of this filing. /s/ Esteban Santos 2026-02-27