Exhibit 4.23

Lan Huang, Ph.D.

Chief Executive Officer

BeyondSpring Pharmaceuticals, Inc.

28 Liberty Street, 39th Floor

New York, NY 10005

Tel: 646.305.6387

January 1, 2020

RE: ANNUAL SALARY RAISE

Edward Dongheng Liu

Dear Edward,

We are pleased to offer you an increase in your annual base salary from $300,000.00 to $430,000.00. In addition, we are increasing your annual bonus opportunity to 45% of annual salary (otherwise subject to the same terms and conditions in your Employment Agreement (defined below). This change will take effect on January 1, 2020.

Except as expressly provided in this letter, your employment agreement with BeyondSpring Pharmaceuticals, Inc., dated as of March 26, 2018, (your “Employment Agreement”) shall remain in full force and effect.

Again, congratulations on your achievement and we wish you all the very best in the coming years. Please let me know if you have any questions regarding your new compensation package.

Sincerely,

/s/ Lan Huang

Lan Huang, Ph.D.

Agreed:

/s/ Edward Dongheng Liu

Edward Dongheng Liu