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Stock-Based Compensation - Assumptions Used to Calculate Fair Values of Options (Details)
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Expected volatility, minimum 90.00% 84.90% 77.20%
Expected volatility, maximum 103.60% 98.30% 85.50%
Risk-free interest rate, minimum 0.60% 0.30% 1.40%
Risk-free interest rate, maximum 1.40% 1.50% 2.50%
Dividend yield 0.00% 0.00% 0.00%
Minimum [Member]      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Expected term 5 years 6 months 5 years 6 months 5 years 4 months 24 days
Maximum      
Share Based Compensation Arrangement By Share Based Payment Award [Line Items]      
Expected term 6 years 1 month 6 days 6 years 1 month 6 days 6 years 1 month 6 days