<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
	<headerData>
        <submissionType>144</submissionType>
                <filerInfo>
            <filer>
                <filerCredentials>
                    <cik>0001676170</cik>
                    <ccc>XXXXXXXX</ccc>
                </filerCredentials>
            </filer>
        <liveTestFlag>LIVE</liveTestFlag>




                </filerInfo>
    </headerData>

     <formData>
        <issuerInfo>
            <issuerCik>0001842295</issuerCik>
			<issuerName>MAZE THERAPEUTICS, INC.</issuerName>


			    <secFileNumber>001-42490</secFileNumber>


			<issuerAddress>
				<com:street1>171 OYSTER POINT BOULEVARD, SUITE 300</com:street1>
                				<com:city>SOUTH SAN FRANCISCO</com:city>
				<com:stateOrCountry>CA</com:stateOrCountry>
				<com:zipCode>94080</com:zipCode>
			</issuerAddress>

			<issuerContactPhone>650-850-5070</issuerContactPhone>
			<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Jason V Coloma</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>

			<relationshipsToIssuer>

				    <relationshipToIssuer>Officer</relationshipToIssuer>

			</relationshipsToIssuer>
		</issuerInfo>

				          <securitiesInformation>
			<securitiesClassTitle>Common Stock</securitiesClassTitle>
			<brokerOrMarketmakerDetails>
				<name>Morgan Stanley Smith Barney LLC</name>
				<address>
				<com:street1>Executive Financial Services</com:street1>
                				<com:street2>1 New York Plaza, 8th Floor</com:street2>
                				<com:city>New York</com:city>
				<com:stateOrCountry>NY</com:stateOrCountry>
				<com:zipCode>10004</com:zipCode>
				</address>
			</brokerOrMarketmakerDetails>
			<noOfUnitsSold>23497</noOfUnitsSold>
			<aggregateMarketValue>623400</aggregateMarketValue>
			<noOfUnitsOutstanding>55549168</noOfUnitsOutstanding>
			<approxSaleDate>09/02/2026</approxSaleDate>
			<securitiesExchangeName>NASDAQ</securitiesExchangeName>
		</securitiesInformation>

    		       <securitiesToBeSold>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <acquiredDate>09/01/2026</acquiredDate>
         <natureOfAcquisitionTransaction>Restricted Stock Unit Vesting</natureOfAcquisitionTransaction>
                  <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
                  <isGiftTransaction>N</isGiftTransaction>
		          <amountOfSecuritiesAcquired>23497</amountOfSecuritiesAcquired>
                  <paymentDate>09/01/2026</paymentDate>
                  <natureOfPayment>Compensation</natureOfPayment>
      </securitiesToBeSold>

    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>


     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Coloma Family Trust DTD 06/27/2016</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>06/22/2026</saleDate>
         <amountOfSecuritiesSold>1953</amountOfSecuritiesSold>
         <grossProceeds>50780.93</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>06/22/2026</saleDate>
         <amountOfSecuritiesSold>2040</amountOfSecuritiesSold>
         <grossProceeds>53040.00</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Coloma Family Trust DTD 06/27/2016</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>06/23/2026</saleDate>
         <amountOfSecuritiesSold>23865</amountOfSecuritiesSold>
         <grossProceeds>621673.70</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>07/01/2026</saleDate>
         <amountOfSecuritiesSold>2593</amountOfSecuritiesSold>
         <grossProceeds>77726.21</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Coloma Family Trust DTD 06/27/2016</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>07/01/2026</saleDate>
         <amountOfSecuritiesSold>31908</amountOfSecuritiesSold>
         <grossProceeds>956526.67</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>08/03/2026</saleDate>
         <amountOfSecuritiesSold>2593</amountOfSecuritiesSold>
         <grossProceeds>69329.14</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Coloma Family Trust DTD 06/27/2016</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>08/03/2026</saleDate>
         <amountOfSecuritiesSold>31908</amountOfSecuritiesSold>
         <grossProceeds>852985.88</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>The Coloma 2021 Irrevocable Trust DTD 09/20/2021</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>09/01/2026</saleDate>
         <amountOfSecuritiesSold>2593</amountOfSecuritiesSold>
         <grossProceeds>68214.05</grossProceeds>
      </securitiesSoldInPast3Months>

     <securitiesSoldInPast3Months>
         <sellerDetails>
            <name>Coloma Family Trust DTD 06/27/2016</name>
            <address>
               <com:street1>c/o Maze Therapeutics, Inc.</com:street1>
                              <com:street2>171 Oyster Point Boulevard, Suite 300</com:street2>
                              <com:city>South San Francisco</com:city>
               <com:stateOrCountry>CA</com:stateOrCountry>
               <com:zipCode>94080</com:zipCode>
            </address>
         </sellerDetails>
         <securitiesClassTitle>Common Stock</securitiesClassTitle>
         <saleDate>09/01/2026</saleDate>
         <amountOfSecuritiesSold>31908</amountOfSecuritiesSold>
         <grossProceeds>838784.74</grossProceeds>
      </securitiesSoldInPast3Months>

    		<remarks>The reported sale was mandated by the Issuer and includes an amount necessary to satisfy tax withholding obligations resulting from the vesting and settlement of restricted stock units granted pursuant to an equity incentive award.</remarks>

        <noticeSignature>
            <noticeDate>09/02/2026</noticeDate>
                        <signature> /s/ Jason V. Coloma</signature>
        </noticeSignature>
	</formData>
    </edgarSubmission>
