SCHEDULE 13G/A 0001776210 XXXXXXXX LIVE 1 Common Stock 12/31/2025 0001674632 Beta Bionics, Inc. 08659B102 11 Hughes Irvine CA 92618 Rule 13d-1(d) Soleus BB SPV, LLC DE 0.00 0.00 0.00 0.00 0.00 N 0.00 PN (1) Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB SPV, LLC ("Soleus BB") and Soleus Private Equity Fund I, L.P. ("Soleus PE Fund I"), and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Capital Management, L.P. ("SCM") is the investment manager for Soleus BB, Soleus PE Fund I, Soleus Private Equity Fund II, L.P. ("Soleus PE Fund II"), and Soleus Capital Master Fund, L.P. ("Master Fund" and, together with Soleus BB, Soleus PE Fund I and Soleus PE Fund II, the "Soleus Funds"), and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of the common stock of Beta Bionics, Inc. (the "Issuer") outstanding as of October 24, 2025, as set forth on the cover of the Issuer's Quarterly Report on Form 10-Q for the fiscal quarter ended September 30, 2025 that was filed with the Securities and Exchange Commission on October 28, 2025 (the "Form 10-Q"). Soleus Private Equity Fund I, L.P. DE 0.00 0.00 0.00 0.00 0.00 N 0.00 PN (1) Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC and Soleus GP, LLC. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Private Equity GP I, LLC DE 0.00 0.00 0.00 0.00 0.00 N 0.00 OO (1) Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC and Soleus GP, LLC. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus PE GP I, LLC DE 0.00 0.00 0.00 0.00 0.00 N 0.00 OO (1) Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC and Soleus GP, LLC. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Private Equity Fund II, L.P. DE 0.00 1703961.00 0.00 1703961.00 1703961.00 N 3.9 PN (1) The shares reported in the table above are held directly by Soleus PE Fund II. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund II, and Soleus PE GP II, LLC is the sole manager of Soleus Private Equity GP II, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Soleus PE Fund II other than for the purpose of determining their obligations under Section 13(d) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Private Equity GP II, LLC DE 0.00 1703961.00 0.00 1703961.00 1703961.00 N 3.9 OO (1) The shares reported in the table above are held directly by Soleus PE Fund II. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund II, and Soleus PE GP II, LLC is the sole manager of Soleus Private Equity GP II, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Soleus PE Fund II other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus PE GP II, LLC DE 0.00 1703961.00 0.00 1703961.00 1703961.00 N 3.9 OO (1) The shares reported in the table above are held directly by Soleus PE Fund II. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund II, and Soleus PE GP II, LLC is the sole manager of Soleus Private Equity GP II, LLC. SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Soleus PE Fund II other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Capital Master Fund, L.P. E9 0.00 799817.00 0.00 799817.00 799817.00 N 1.8 FI (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, Soleus Capital Group, LLC ("SCG") is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Capital, LLC DE 0.00 799817.00 0.00 799817.00 799817.00 N 1.8 OO (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Capital Group, LLC DE 0.00 799817.00 0.00 799817.00 799817.00 N 1.8 OO (1) The shares reported in the table above are held directly by Master Fund. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held by Master Fund other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus Capital Management, L.P. DE 0.00 2503778.00 0.00 2503778.00 2503778.00 N 5.7 PN (1) The shares reported in the table above are held directly by the Soleus Funds. Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP I, LLC, Soleus Private Equity GP I, LLC, Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by the Soleus Funds other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Soleus GP, LLC DE 0.00 2503778.00 0.00 2503778.00 2503778.00 N 5.7 OO (1) The shares reported in the table above are held directly by the Soleus Funds. Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP I, LLC, Soleus Private Equity GP I, LLC, Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by the Soleus Funds other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Guy Levy X1 30787.00 2503778.00 30787.00 2503778.00 2534565.00 N 5.8 IN (1) The shares reported in the table above are held directly by the Soleus Funds. Soleus Private Equity GP I, LLC is the sole general partner of Soleus BB and Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Private Equity GP II, LLC is the sole general partner of Soleus PE Fund I, and Soleus PE GP I, LLC is the sole manager of Soleus Private Equity GP I, LLC. Soleus Capital, LLC is the sole general partner of Master Fund, SCG is the sole managing member of Soleus Capital, LLC, SCM is the investment manager for the Soleus Funds, and Soleus GP, LLC is the sole general partner of SCM. Guy Levy is the sole managing member of each of Soleus PE GP I, LLC, Soleus PE GP II, LLC, and Soleus GP, LLC. Each of Soleus PE GP I, LLC, Soleus Private Equity GP I, LLC, Soleus PE GP II, LLC, Soleus Private Equity GP II, LLC, SCG, Soleus Capital, LLC, SCM, Soleus GP, LLC and Mr. Levy disclaims beneficial ownership of these shares held directly by the Soleus Funds other than for the purpose of determining their obligations under Section 13(d) of the Exchange Act, and the filing of this report shall not be deemed an admission that any of the foregoing persons is the beneficial owner of such shares for any other purpose. (2) The percentage listed in row 11 is calculated based upon 44,024,631 shares of common stock of the Issuer outstanding as of October 24, 2025, as set forth on the cover of the Form 10-Q. Beta Bionics, Inc. 11 Hughes Irvine, California 92618 Soleus BB SPV, LLC Soleus Private Equity Fund I, L.P. Soleus Private Equity GP I, LLC Soleus PE GP I, LLC Soleus Private Equity Fund II, L.P. Soleus Private Equity GP II, LLC Soleus PE GP II, LLC Soleus Capital Master Fund, L.P. Soleus Capital, LLC Soleus Capital Group, LLC Soleus Capital Management, L.P. Soleus GP, LLC Guy Levy Soleus BB SPV, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Private Equity Fund I, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Private Equity GP I, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus PE GP I, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Private Equity Fund II, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Private Equity GP II, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus PE GP II, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Master Fund, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Group, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus Capital Management, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus GP, LLC 100 Field Point Road, Suite 200 Greenwich, CT 06830 Guy Levy c/o Soleus Capital Management, L.P. 100 Field Point Road, Suite 200 Greenwich, CT 06830 Soleus BB SPV, LLC - Delaware Soleus Private Equity Fund I, L.P. - Delaware Soleus Private Equity GP I, LLC - Delaware Soleus PE GP I, LLC - Delaware Soleus Private Equity Fund II, L.P. - Delaware Soleus Private Equity GP II, LLC - Delaware Soleus PE GP II, LLC - Delaware Soleus Capital Master Fund, L.P. - Cayman Islands Soleus Capital, LLC - Delaware Soleus Capital Group, LLC - Delaware Soleus Capital Management, L.P. - Delaware Soleus GP, LLC - Delaware Guy Levy - United States Y The information in rows 5 through 9 and 11 on the cover pages to this Schedule 13G, including the footnotes thereto, which reflects beneficial ownership of the Common Stock of the Issuer as of Mach 31, 2025, is hereby incorporated by reference. Soleus BB SPV, LLC - 0 Soleus Private Equity Fund I, L.P. - 0 Soleus Private Equity GP I, LLC - 0 Soleus PE GP I, LLC - 0 Soleus Private Equity Fund II, L.P. - 1,703,961 Soleus Private Equity GP II, LLC - 1,703,961 Soleus PE GP II, LLC - 1,703,961 Soleus Capital Master Fund, L.P. - 799,817 Soleus Capital, LLC - 799,817 Soleus Capital Group, LLC - 799,817 Soleus Capital Management, L.P. - 2,503,778 Soleus GP, LLC - 2,503,778 Guy Levy - 2,503,778 Soleus BB SPV, LLC - 0% Soleus Private Equity Fund I, L.P. - 0% Soleus Private Equity GP I, LLC - 0% Soleus PE GP I, LLC - 0% Soleus Private Equity Fund II, L.P. - 3.9% Soleus Private Equity GP II, LLC - 3.9% Soleus PE GP II, LLC - 3.9% Soleus Capital Master Fund, L.P. - 1.8% Soleus Capital, LLC - 1.8% Soleus Capital Group, LLC - 1.8% Soleus Capital Management, L.P. - 5.7% Soleus GP, LLC - 5.7% Guy Levy - 5.8% Guy Levy - 30,787 Soleus BB SPV, LLC - 0 Soleus Private Equity Fund I, L.P. - 0 Soleus Private Equity GP I, LLC - 0 Soleus PE GP I, LLC - 0 Soleus Private Equity Fund II, L.P. - 1,703,961 Soleus Private Equity GP II, LLC - 1,703,961 Soleus PE GP II, LLC - 1,703,961 Soleus Capital Master Fund, L.P. - 799,817 Soleus Capital, LLC - 799,817 Soleus Capital Group, LLC - 799,817 Soleus Capital Management, L.P. - 2,503,778 Soleus GP, LLC - 2,503,778 Guy Levy - 2,503,778 Guy Levy - 30-787 Soleus BB SPV, LLC - 0 Soleus Private Equity Fund I, L.P. - 0 Soleus Private Equity GP I, LLC - 0 Soleus PE GP I, LLC - 0 Soleus Private Equity Fund II, L.P. - 1,703,961 Soleus Private Equity GP II, LLC - 1,703,961 Soleus PE GP II, LLC - 1,703,961 Soleus Capital Master Fund, L.P. - 799,817 Soleus Capital, LLC - 799,817 Soleus Capital Group, LLC - 799,817 Soleus Capital Management, L.P. - 2,503,778 Soleus GP, LLC - 2,503,778 Guy Levy - 2,503,778 Y Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11. Soleus BB SPV, LLC /s/ Guy Levy 02/12/2026 Soleus Private Equity Fund I, L.P. /s/ Guy Levy 02/12/2026 Soleus Private Equity GP I, LLC /s/ Guy Levy 02/12/2026 Soleus PE GP I, LLC /s/ Guy Levy 02/12/2026 Soleus Private Equity Fund II, L.P. /s/ Guy Levy 02/12/2026 Soleus Private Equity GP II, LLC /s/ Guy Levy 02/12/2026 Soleus PE GP II, LLC /s/ Guy Levy 02/12/2026 Soleus Capital Master Fund, L.P. /s/ Guy Levy 02/12/2026 Soleus Capital, LLC /s/ Guy Levy 02/12/2026 Soleus Capital Group, LLC /s/ Guy Levy 02/12/2026 Soleus Capital Management, L.P. /s/ Guy Levy 02/12/2026 Soleus GP, LLC /s/ Guy Levy 02/12/2026 Guy Levy /s/ Guy Levy 02/12/2026