0000950123-23-002442.txt : 20230214 0000950123-23-002442.hdr.sgml : 20230214 20230214124400 ACCESSION NUMBER: 0000950123-23-002442 CONFORMED SUBMISSION TYPE: 13F-HR PUBLIC DOCUMENT COUNT: 2 CONFORMED PERIOD OF REPORT: 20221231 FILED AS OF DATE: 20230214 DATE AS OF CHANGE: 20230214 EFFECTIVENESS DATE: 20230214 FILER: COMPANY DATA: COMPANY CONFORMED NAME: Bellevue Group AG CENTRAL INDEX KEY: 0001674546 IRS NUMBER: 000000000 STATE OF INCORPORATION: V8 FISCAL YEAR END: 1231 FILING VALUES: FORM TYPE: 13F-HR SEC ACT: 1934 Act SEC FILE NUMBER: 028-17462 FILM NUMBER: 23625803 BUSINESS ADDRESS: STREET 1: SEESTRASSE 16 CITY: KUESNACHT STATE: V8 ZIP: 8700 BUSINESS PHONE: 41 44 267 67 77 MAIL ADDRESS: STREET 1: SEESTRASSE 16 CITY: KUESNACHT STATE: V8 ZIP: 8700 13F-HR 1 primary_doc.xml X0202 13F-HR LIVE 0001674546 XXXXXXXX 12-31-2022 12-31-2022 false Bellevue Group AG
Seestrasse 16 Kuesnacht V8 8700
13F HOLDINGS REPORT 028-17462 028-17462 N
Christoph Eisenring / Michael Hutter Head Legal & Compliance / CFO 41 (44) 267 67 77 /s/ Christoph Eisenring / /s/ Michael Hutter Kuesnacht V8 02-10-2023 3 215 7534625383 false 1 28-06964 BB Biotech AG 2 28-16892 Bellevue Asset Management AG 3 28-20408 Bellevue Asset Management (UK) Ltd.
INFORMATION TABLE 2 21078.xml INFORMATION TABLE FOR FORM 13F 10X GENOMICS INC CL A COM 88025U109 11833744 324746 SH DFND 2 324746 0 0 ABBOTT LABS COM 002824100 184938949 1684479 SH DFND 2 1684479 0 0 ABBVIE INC COM 00287Y109 2618082 16200 SH DFND 2 16200 0 0 ACADIA HEALTHCARE CO IN COM 00404A109 105946 1287 SH DFND 2 1287 0 0 ACCOLADE INC COM 00437E102 4948457 635232 SH DFND 2 635232 0 0 ACCOLADE INC COM 00437E102 23697531 3042045 SH DFND 3 3042045 0 0 ADAPTIVE BIOTECHNOLOGIES COR COM 00650F109 22615401 2960131 SH DFND 3 2960131 0 0 AGILENT TECHNOLOGIES INC COM 00846U101 1193908 7978 SH DFND 2 7978 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 730080 26000 SH DFND 2 26000 0 0 AGIOS PHARMACEUTICALS INC COM 00847X104 113184639 4030792 SH DFND 1,2 4030792 0 0 AKERO THERAPEUTICS INC COM 00973Y108 2337220 42650 SH DFND 2 42650 0 0 ALIGN TECHNOLOGY INC COM 016255101 16702015 79194 SH DFND 2 79194 0 0 ALKERMES PLC SHS G01767105 1580865 35500 SH DFND 2 35500 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 7417769 31213 SH DFND 2 31213 0 0 ALNYLAM PHARMACEUTICALS INC COM 02043Q107 211508500 890000 SH DFND 1,2 890000 0 0 ALPHABET INC CAP STK CL C 02079K107 532380 6000 SH DFND 2 6000 0 0 AMEDISYS INC COM 023436108 6360234 76134 SH DFND 2 76134 0 0 AMEDISYS INC COM 023436108 44892558 537378 SH DFND 3 537378 0 0 AMERICAN WELL CORP CL A 03044L105 5525334 1952415 SH DFND 2 1952415 0 0 AMERISOURCEBERGEN CORP COM 03073E105 1691899 10210 SH DFND 2 10210 0 0 AMGEN INC COM 031162100 10226939 38939 SH DFND 2 38939 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 1835705 35500 SH DFND 2 35500 0 0 APELLIS PHARMACEUTICALS INC COM 03753U106 55263356 1068717 SH DFND 3 1068717 0 0 ARCUS BIOSCIENCES INC COM 03969F109 1362068 65864 SH DFND 2 65864 0 0 ARGENX SE SPONSORED ADR 04016X101 7045102 18597 SH DFND 2 18597 0 0 ARGENX SE SPONSORED ADR 04016X101 338106911 892503 SH DFND 1,2 892503 0 0 ARROWHEAD PHARMACEUTICALS IN COM 04280A100 863928 21300 SH DFND 2 21300 0 0 ARVINAS INC COM 04335A105 478940 14000 SH DFND 2 14000 0 0 ARVINAS INC COM 04335A105 73086655 2136412 SH DFND 1,2 2136412 0 0 ASTRAZENECA PLC SPONSORED ADR 046353108 4648252 68500 SH DFND 2 68500 0 0 ATRICURE INC COM 04963C209 28585557 644109 SH DFND 3 644109 0 0 AURINIA PHARMACEUTICALS INC COM 05156V102 5574001 1290278 SH DFND 3 1290278 0 0 AVANTOR INC COM 05352A100 9946487 471621 SH DFND 2 471621 0 0 AXONICS INC COM 05465P101 49286271 788202 SH DFND 2 788202 0 0 AXONICS INC COM 05465P101 69924735 1118259 SH DFND 3 1118259 0 0 AXSOME THERAPEUTICS INC COM 05464T104 58850 763 SH DFND 2 763 0 0 AXSOME THERAPEUTICS INC COM 05464T104 33620581 435895 SH DFND 3 435895 0 0 BAXTER INTL INC COM 071813109 16345111 320681 SH DFND 2 320681 0 0 BEAM THERAPEUTICS INC COM 07373V105 140796 3600 SH DFND 2 3600 0 0 BEAM THERAPEUTICS INC COM 07373V105 27107962 693121 SH DFND 1,2 693121 0 0 BECTON DICKINSON & CO COM 075887109 84315708 331560 SH DFND 2 331560 0 0 BEIGENE LTD SPONSORED ADR 07725L102 7714819 34500 SH DFND 2 34500 0 0 BELLUS HEALTH INC COM NEW 07987C204 369119 44905 SH DFND 2 44905 0 0 BERKELEY LTS INC COM 084310101 1031838 385014 SH DFND 2 385014 0 0 BICYCLE THERAPEUTICS PLC SPONSORED ADS 088786108 2077920 70200 SH DFND 2 70200 0 0 BIOGEN INC COM 09062X103 7865636 28404 SH DFND 2 28404 0 0 BIOMARIN PHARMACEUTICAL INC COM 09061G101 6280291 60685 SH DFND 2 60685 0 0 BIONTECH SE SPONSORED ADS 09075V102 33210638 221080 SH DFND 2 221080 0 0 BIO RAD LABS INC CL A 090572207 46740827 111158 SH DFND 3 111158 0 0 BLACK DIAMOND THERAPEUTICS I COM 09203E105 41400 23000 SH DFND 2 23000 0 0 BLACK DIAMOND THERAPEUTICS I COM 09203E105 9680110 5377839 SH DFND 1,2 5377839 0 0 BOSTON SCIENTIFIC CORP COM 101137107 180588293 3902924 SH DFND 2 3902924 0 0 BRISTOL-MYERS SQUIBB CO COM 110122108 3615847 50255 SH DFND 2 50255 0 0 CARDINAL HEALTH INC COM 14149Y108 814822 10600 SH DFND 2 10600 0 0 CAREDX INC COM 14167L103 36151992 3168448 SH DFND 3 3168448 0 0 CASTLE BIOSCIENCES INC COM 14843C105 22229104 944312 SH DFND 3 944312 0 0 CELLDEX THERAPEUTICS INC COM NEW 15117B202 80226000 1800000 SH DFND 1,2 1800000 0 0 CENTENE CORP DEL COM 15135B101 56878692 693558 SH DFND 2 693558 0 0 CHARLES RIV LABS INTL INC COM 159864107 63185988 289977 SH DFND 3 289977 0 0 CIGNA CORP NEW COM 125523100 52557482 158621 SH DFND 2 158621 0 0 COOPER COS INC COM NEW 216648402 26887770 81313 SH DFND 2 81313 0 0 CRISPR THERAPEUTICS AG NAMEN AKT H17182108 939015 23100 SH DFND 2 23100 0 0 CRISPR THERAPEUTICS AG NAMEN AKT H17182108 36121793 888605 SH DFND 1,2 888605 0 0 CVS HEALTH CORP COM 126650100 19029864 204205 SH DFND 2 204205 0 0 CYTOKINETICS INC COM NEW 23282W605 2483444 54200 SH DFND 2 54200 0 0 DANAHER CORPORATION COM 235851102 97236617 366350 SH DFND 2 366350 0 0 DENALI THERAPEUTICS INC COM 24823R105 862110 31000 SH DFND 2 31000 0 0 DESIGN THERAPEUTICS INC COM 25056L103 357879 34881 SH DFND 2 34881 0 0 DEXCOM INC COM 252131107 111935022 988476 SH DFND 2 988476 0 0 DOLBY LABORATORIES INC COM CL A 25659T107 112864 1600 SH DFND 2 1600 0 0 DOXIMITY INC CL A 26622P107 15054311 448579 SH DFND 2 448579 0 0 DR REDDYS LABS LTD ADR 256135203 6430506 125500 SH DFND 2 125500 0 0 EDWARDS LIFESCIENCES CORP COM 28176E108 79394814 1064131 SH DFND 2 1064131 0 0 ELEVANCE HEALTH INC COM 036752103 41733187 81356 SH DFND 2 81356 0 0 ELEVANCE HEALTH INC COM 036752103 34915303 68065 SH DFND 3 68065 0 0 LILLY ELI & CO COM 532457108 4044361 11055 SH DFND 2 11055 0 0 EQUINIX INC COM 29444U700 26201 40 SH DFND 2 40 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 848526 136200 SH DFND 2 136200 0 0 ESPERION THERAPEUTICS INC NE COM 29664W105 26129019 4194064 SH DFND 1,2 4194064 0 0 ESSA PHARMA INC COM NEW 29668H708 47880 19000 SH DFND 2 19000 0 0 ESSA PHARMA INC COM NEW 29668H708 19856549 7879583 SH DFND 1,2 7879583 0 0 EVERTEC INC COM 30040P103 23929 739 SH DFND 2 739 0 0 EVOLENT HEALTH INC CL A 30050B101 12413410 442073 SH DFND 2 442073 0 0 EVOLENT HEALTH INC CL A 30050B101 43287566 1541580 SH DFND 3 1541580 0 0 EXACT SCIENCES CORP COM 30063P105 8805502 177853 SH DFND 2 177853 0 0 EXACT SCIENCES CORP COM 30063P105 56152361 1134162 SH DFND 3 1134162 0 0 EXELIXIS INC COM 30161Q104 304760 19000 SH DFND 2 19000 0 0 EXELIXIS INC COM 30161Q104 42578180 2654500 SH DFND 1,2 2654500 0 0 FATE THERAPEUTICS INC COM 31189P102 216935 21500 SH DFND 2 21500 0 0 FATE THERAPEUTICS INC COM 31189P102 48833370 4839779 SH DFND 1,2 4839779 0 0 GENERATION BIO CO COM 37148K100 74670 19000 SH DFND 2 19000 0 0 GENERATION BIO CO COM 37148K100 14180540 3608280 SH DFND 1,2 3608280 0 0 GILEAD SCIENCES INC COM 375558103 11189947 130343 SH DFND 2 130343 0 0 GLOBUS MED INC CL A 379577208 50516969 680180 SH DFND 2 680180 0 0 GRUPO AEROPORTUARIO DEL SURE SPON ADR SER B 40051E202 157 135 SH DFND 2 135 0 0 GUARDANT HEALTH INC COM 40131M109 3684376 135455 SH DFND 2 135455 0 0 HALOZYME THERAPEUTICS INC COM 40637H109 46242630 812700 SH DFND 2 812700 0 0 HARMONY BIOSCIENCES HLDGS IN COM 413197104 32850179 596192 SH DFND 2 596192 0 0 HCA HEALTHCARE INC COM 40412C101 79500188 331306 SH DFND 2 331306 0 0 HOLOGIC INC COM 436440101 18191623 243171 SH DFND 2 243171 0 0 HOMOLOGY MEDICINES INC COM 438083107 2044378 1622522 SH DFND 1,2 1622522 0 0 HORIZON THERAPEUTICS PUB L SHS G46188101 1412372 12411 SH DFND 2 12411 0 0 HUMANA INC COM 444859102 56616970 110539 SH DFND 2 110539 0 0 HUTCHMED CHINA LTD SPONSORED ADS 44842L103 284255 17800 SH DFND 2 17800 0 0 HUTCHMED CHINA LTD SPONSORED ADS 44842L103 28143506 1762344 SH DFND 3 1762344 0 0 IDEXX LABS INC COM 45168D104 44395023 108822 SH DFND 2 108822 0 0 ILLUMINA INC COM 452327109 19190195 94907 SH DFND 2 94907 0 0 INCYTE CORP COM 45337C102 5293088 65900 SH DFND 2 65900 0 0 INCYTE CORP COM 45337C102 232211305 2891077 SH DFND 1,2 2891077 0 0 INFOSYS LTD SPONSORED ADR 456788108 20607 1130 SH DFND 2 1130 0 0 INHIBRX INC COM 45720L107 731808 29700 SH DFND 2 29700 0 0 INSMED INC COM PAR $.01 457669307 65478596 3277207 SH DFND 3 3277207 0 0 INSPIRE MED SYS INC COM 457730109 101190775 401742 SH DFND 2 401742 0 0 INSULET CORP COM 45784P101 101794174 345780 SH DFND 2 345780 0 0 INTRA-CELLULAR THERAPIES INC COM 46116X101 2686060 50757 SH DFND 2 50757 0 0 INTRA-CELLULAR THERAPIES INC COM 46116X101 174185069 3291479 SH DFND 1,2 3291479 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 224526168 846151 SH DFND 2 846151 0 0 INTUITIVE SURGICAL INC COM NEW 46120E602 29436602 110935 SH DFND 3 110935 0 0 IONIS PHARMACEUTICALS INC COM 462222100 4113153 108900 SH DFND 2 108900 0 0 IONIS PHARMACEUTICALS INC COM 462222100 363913950 9635000 SH DFND 1,2 9635000 0 0 IPG PHOTONICS CORP COM 44980X109 99404 1050 SH DFND 2 1050 0 0 IQVIA HLDGS INC COM 46266C105 37560435 183320 SH DFND 2 183320 0 0 ISHARES TR MSCI CHINA ETF 46429B671 194750 4100 SH DFND 2 4100 0 0 IVERIC BIO INC COM 46583P102 894938 41800 SH DFND 2 41800 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 43648072 273982 SH DFND 2 273982 0 0 JAZZ PHARMACEUTICALS PLC SHS USD G50871105 76891609 482654 SH DFND 3 482654 0 0 JOHNSON & JOHNSON COM 478160104 4597670 26027 SH DFND 2 26027 0 0 JUMIA TECHNOLOGIES AG SPONSORED ADS 48138M105 57780 18000 SH DFND 2 18000 0 0 KARUNA THERAPEUTICS INC COM 48576A100 1434450 7300 SH DFND 2 7300 0 0 KEZAR LIFE SCIENCES INC COM 49372L100 218240 31000 SH DFND 2 31000 0 0 KEZAR LIFE SCIENCES INC COM 49372L100 21120000 3000000 SH DFND 1,2 3000000 0 0 KOSMOS ENERGY LTD COM 500688106 2024388 318300 SH DFND 2 318300 0 0 KRYSTAL BIOTECH INC COM 501147102 1449726 18300 SH DFND 2 18300 0 0 LABORATORY CORP AMER HLDGS COM NEW 50540R409 784148 3330 SH DFND 2 3330 0 0 LEGEND BIOTECH CORP SPONSORED ADS 52490G102 17711067 354789 SH DFND 2 354789 0 0 MACROGENICS INC COM 556099109 335165 49950 SH DFND 2 49950 0 0 MACROGENICS INC COM 556099109 59920052 8929963 SH DFND 1,2 8929963 0 0 MARKETAXESS HLDGS INC COM 57060D108 184625 662 SH DFND 2 662 0 0 MCKESSON CORP COM 58155Q103 1095350 2920 SH DFND 2 2920 0 0 MEDTRONIC PLC SHS G5960L103 48063602 618420 SH DFND 2 618420 0 0 MERCADOLIBRE INC COM 58733R102 143861 170 SH DFND 2 170 0 0 MERCK & CO INC COM 58933Y105 749023 6751 SH DFND 2 6751 0 0 MERSANA THERAPEUTICS INC COM 59045L106 1268104 216400 SH DFND 2 216400 0 0 MERSANA THERAPEUTICS INC COM 59045L106 23827932 4066200 SH DFND 1,2 4066200 0 0 MERUS N V COM N5749R100 706979 45700 SH DFND 2 45700 0 0 MODERNA INC COM 60770K107 14437317 80377 SH DFND 2 80377 0 0 MODERNA INC COM 60770K107 269780439 1501951 SH DFND 1,2 1501951 0 0 MOLECULAR TEMPLATES INC COM 608550109 28208 86000 SH DFND 2 86000 0 0 MOLECULAR TEMPLATES INC COM 608550109 3670977 11192003 SH DFND 1,2 11192003 0 0 MOLINA HEALTHCARE INC COM 60855R100 61425543 186014 SH DFND 2 186014 0 0 MYOVANT SCIENCES LTD COM G637AM102 1024480 38000 SH DFND 2 38000 0 0 MYOVANT SCIENCES LTD COM G637AM102 158326347 5872639 SH DFND 1,2 5872639 0 0 NATERA INC COM 632307104 6982028 173812 SH DFND 2 173812 0 0 NEKTAR THERAPEUTICS COM 640268108 33448 14800 SH DFND 2 14800 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 5171035 43294 SH DFND 2 43294 0 0 NEUROCRINE BIOSCIENCES INC COM 64125C109 326071200 2730000 SH DFND 1,2 2730000 0 0 NEVRO CORP COM 64157F103 10329066 260835 SH DFND 2 260835 0 0 NOVOCURE LTD ORD SHS G6674U108 660000 9000 SH DFND 2 9000 0 0 OLINK HLDG AB SPONSORED ADS 680710100 6375075 251185 SH DFND 2 251185 0 0 OMNICELL COM COM 68213N109 26136921 518384 SH DFND 2 518384 0 0 OPTHEA LTD SPONSORED ADS 68386J208 234601 47000 SH DFND 2 47000 0 0 OPTION CARE HEALTH INC COM NEW 68404L201 73131398 2430422 SH DFND 3 2430422 0 0 OUTSET MED INC COM 690145107 25999578 1006955 SH DFND 2 1006955 0 0 OUTSET MED INC COM 690145107 47424214 1836724 SH DFND 3 1836724 0 0 PACIFIC BIOSCIENCES CALIF IN COM 69404D108 22892630 2798610 SH DFND 2 2798610 0 0 PACIFIC BIOSCIENCES CALIF IN COM 69404D108 30104977 3680315 SH DFND 3 3680315 0 0 PENUMBRA INC COM 70975L107 50235250 225817 SH DFND 2 225817 0 0 PFIZER INC COM 717081103 40411605 788673 SH DFND 2 788673 0 0 PHREESIA INC COM 71944F106 21565319 666419 SH DFND 2 666419 0 0 PRIVIA HEALTH GROUP INC COM 74276R102 20454125 900666 SH DFND 2 900666 0 0 PROCEPT BIOROBOTICS CORP COM 74276L105 30802616 741517 SH DFND 2 741517 0 0 REGENERON PHARMACEUTICALS COM 75886F107 11311520 15678 SH DFND 2 15678 0 0 RELAY THERAPEUTICS INC COM 75943R102 1256454 84100 SH DFND 2 84100 0 0 RELAY THERAPEUTICS INC COM 75943R102 61563557 4120720 SH DFND 1,2 4120720 0 0 RESMED INC COM 761152107 20453976 98275 SH DFND 2 98275 0 0 REVOLUTION MEDICINES INC COM 76155X100 1848432 77600 SH DFND 2 77600 0 0 REVOLUTION MEDICINES INC COM 76155X100 113801527 4777562 SH DFND 1,2 4777562 0 0 ROCKET PHARMACEUTICALS INC COM 77313F106 716262 36600 SH DFND 2 36600 0 0 SAGE THERAPEUTICS INC COM 78667J108 724660 19000 SH DFND 2 19000 0 0 SAGE THERAPEUTICS INC COM 78667J108 112523603 2950278 SH DFND 1,2 2950278 0 0 SAREPTA THERAPEUTICS INC COM 803607100 4046913 31231 SH DFND 2 31231 0 0 SAREPTA THERAPEUTICS INC COM 803607100 85779109 661978 SH DFND 3 661978 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 174665 19300 SH DFND 2 19300 0 0 SCHOLAR ROCK HLDG CORP COM 80706P103 19301161 2132725 SH DFND 1,2 2132725 0 0 SEAGEN INC COM 81181C104 2907667 22626 SH DFND 2 22626 0 0 SEER INC COM CL A 81578P106 789571 136133 SH DFND 2 136133 0 0 SHOCKWAVE MED INC COM 82489T104 50912326 247616 SH DFND 2 247616 0 0 SIGHT SCIENCES INC COM 82657M105 3597139 294606 SH DFND 2 294606 0 0 SILK RD MED INC COM 82710M100 53511841 1012523 SH DFND 3 1012523 0 0 SPDR S&P 500 ETF TR TR UNIT 78462F103 688374 1800 SH DFND 2 1800 0 0 SPDR SER TR S&P OILGAS EXP 78468R556 529932 3900 SH DFND 2 3900 0 0 STRYKER CORPORATION COM 863667101 120346291 492234 SH DFND 2 492234 0 0 SUPERNUS PHARMACEUTICALS INC COM 868459108 3961011 111046 SH DFND 2 111046 0 0 TAIWAN SEMICONDUCTOR MFG LTD SPONSORED ADS 874039100 1249 770 SH DFND 2 770 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 26554932 590766 SH DFND 2 590766 0 0 TANDEM DIABETES CARE INC COM NEW 875372203 53970746 1200684 SH DFND 3 1200684 0 0 TELADOC HEALTH INC COM 87918A105 9230264 390286 SH DFND 2 390286 0 0 TELEFLEX INCORPORATED COM 879369106 6257226 25066 SH DFND 2 25066 0 0 THERMO FISHER SCIENTIFIC INC COM 883556102 45888447 83329 SH DFND 2 83329 0 0 TRANSMEDICS GROUP INC COM 89377M109 42096620 682058 SH DFND 2 682058 0 0 UNITED MICROELECTRONICS CORP SPON ADR NEW 910873405 17867 2698 SH DFND 2 2698 0 0 UNITED THERAPEUTICS CORP DEL COM 91307C102 58955 212 SH DFND 2 212 0 0 UNITEDHEALTH GROUP INC COM 91324P102 76235643 143792 SH DFND 2 143792 0 0 UNITEDHEALTH GROUP INC COM 91324P102 42680550 80502 SH DFND 3 80502 0 0 VANECK ETF TRUST GOLD MINERS ETF 92189F106 527344 18400 SH DFND 2 18400 0 0 VANECK ETF TRUST JUNIOR GOLD MINE 92189F791 178250 5000 SH DFND 2 5000 0 0 VEEVA SYS INC CL A COM 922475108 30058155 186257 SH DFND 2 186257 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 12773606 44233 SH DFND 2 44233 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 35020928 121272 SH DFND 3 121272 0 0 VERTEX PHARMACEUTICALS INC COM 92532F100 268716432 930523 SH DFND 1,2 930523 0 0 VIRIDIAN THERAPEUTICS INC COM 92790C104 1346581 46100 SH DFND 2 46100 0 0 WAVE LIFE SCIENCES LTD SHS Y95308105 31461206 4494458 SH DFND 1,2 4494458 0 0 XENCOR INC COM 98401F105 661416 25400 SH DFND 2 25400 0 0 ZAI LAB LTD ADR 98887Q104 2837843 90000 SH DFND 2 90000 0 0 ZIMMER BIOMET HOLDINGS INC COM 98956P102 33952740 266296 SH DFND 2 266296 0 0