Commitments and Contingencies - Additional Information (Detail) - USD ($) $ in Millions	1 Months Ended
	Jul. 31, 2020	Nov. 30, 2019	Mar. 31, 2021
Contingencies And Commitments [Line Items]
Rental payments period	152 months	5 years
Letter of Credit [Member]
Contingencies And Commitments [Line Items]
Letters of credit secured by cash held in restricted depository account			$ 16.8
Lease Arrangement [Member]
Contingencies And Commitments [Line Items]
Annual rental payments		$ 3.9
Lease Arrangement [Member] | Minimum [Member]
Contingencies And Commitments [Line Items]
Rental payments	$ 292.5
2015 Collaboration Agreement [Member] | Vertex Pharmaceuticals Incorporated and Certain of its Subsidiaries [Member]
Contingencies And Commitments [Line Items]
Milestone payment receivable			$ 395.0