Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2021	Dec. 31, 2020
Current assets:
Cash and cash equivalents	$ 1,126,059	$ 1,168,620
Marketable securities	680,144	521,713
Accounts receivable	150	144
Prepaid expenses and other current assets	26,006	26,143
Total current assets	1,832,359	1,716,620
Property and equipment, net	51,913	42,160
Intangible assets, net	167	180
Restricted cash	16,844	16,848
Operating lease assets	50,129	50,865
Other non-current assets	6,498	1,293
Total assets	1,957,910	1,827,966
Current liabilities:
Accounts payable	13,072	9,094
Accrued expenses	49,864	53,782
Deferred revenue, current	1,802	2,341
Accrued tax liabilities	3,356	10,473
Operating lease liabilities	12,063	11,362
Other current liabilities	2,933	7,207
Total current liabilities	83,090	94,259
Deferred revenue, non-current	11,776	11,776
Operating lease liabilities, net of current portion	49,408	50,067
Other non-current liabilities	8,138	7,630
Total liabilities	152,412	163,732
Commitments and contingencies, see Note 6
Shareholders’ equity:
Common shares, CHF 0.03 par value, 115,172,786 shares authorized at March 31, 2021 and December 31, 2020, 75,925,944 and 74,110,160 shares issued at March 31, 2021 and December 31, 2020, respectively, 75,730,628 and 73,914,844 shares outstanding at March 31, 2021 and December 31, 2020, respectively.	2,340	2,277
Treasury shares, at cost, 195,316 shares at March 31, 2021 and December 31, 2020.	(63)	(63)
Additional paid-in capital	2,490,421	2,235,679
Accumulated deficit	(686,739)	(573,576)
Accumulated other comprehensive loss	(461)	(83)
Total shareholders' equity	1,805,498	1,664,234
Total liabilities and shareholders’ equity	$ 1,957,910	$ 1,827,966