Selected Quarterly Financial Data (Unaudited) (Tables)

12 Months Ended

Dec. 31, 2019

Quarterly Financial Information Disclosure [Abstract]

Selected Quarterly Financial Data

The following table sets forth the Company’s quarterly financial data for the two years ended December 31, 2019.   

	2019
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter
Collaboration revenue	$	328		$	318		$	211,928		$	77,016
Total operating expenses		48,751			55,301			72,765		$	66,033
(Loss) income from operations		(48,423	)		(54,983	)		139,163		$	10,983
Net (loss) income		(48,408	)		(53,699	)		138,423		$	30,542
Net (loss) income per share attributable to common shareholders:
Basic	$	(0.93	)	$	(1.01	)		2.52		$	0.53
Diluted	$	(0.93	)	$	(1.01	)	$	2.40		$	0.51
Weighted-average common shares outstanding used in net (loss)    income per share attributable to common shareholders:
Basic		52,093,208			53,188,041			54,829,057			57,395,839
Diluted		52,093,208			53,188,041			57,598,901			60,233,927
	2018
	First Quarter			Second Quarter			Third Quarter			Fourth Quarter
Collaboration revenue	$	1,358		$	1,088		$	563		$	115
Total operating expenses		28,355			38,374			49,995		$	45,343
Loss from operations		(26,997	)		(37,286	)		(49,432	)	$	(45,228	)
Net loss		(28,300	)		(38,380	)		(50,711	)	$	(47,590	)
Net loss per share attributable to common shareholders:
Basic	$	(0.62	)	$	(0.82	)	$	(1.07	)	$	(0.92	)
Diluted	$	(0.62	)	$	(0.82	)	$	(1.07	)	$	(0.92	)
Weighted-average common shares outstanding used in net loss    per share attributable to common shareholders:
Basic		45,877,428			46,842,316			47,391,988			51,688,383
Diluted		45,877,428			46,842,316			47,391,988			51,688,383