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Summary of Significant Accounting Policies - Impact of New Revenue Guidance on Financial Statement Line Items (Parenthetical) (Detail) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2018
Jun. 30, 2017
Jun. 30, 2018
Jun. 30, 2017
Jan. 01, 2018
Dec. 31, 2017
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]            
Accumulated deficit $ (193,268)   $ (193,268)     $ (125,440)
Research and development [1] 25,633 $ 17,120 45,152 $ 31,925    
ASU 2014-09 [Member]            
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]            
Accumulated deficit         $ (126,588)  
ASU 2014-09 [Member] | ASC 606 Adjustment [Member]            
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]            
Deferred revenue         1,148  
Accumulated deficit 953   953   $ (1,148)  
Research and development 68   144      
Non-exclusive research revenue 26   51      
ASU 2014-09 [Member] | ASC 606 Adjustment [Member] | Other Current Liabilities [Member]            
New Accounting Pronouncements Or Change In Accounting Principle [Line Items]            
Deferred revenue current $ 102   $ 102      
[1] Including the following research and development expense with a related party, see Note 10: