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Related Party Transactions - Additional Information (Detail) - USD ($)
$ in Thousands
1 Months Ended 12 Months Ended
Oct. 31, 2016
Oct. 31, 2016
Dec. 31, 2016
Dec. 31, 2015
Related Party Transaction [Line Items]        
Issuance of convertible loans     $ 35,010 $ 38,239
Proceeds from issuance of common shares in private placement     35,000  
Investors [Member] | Series A-3 Redeemable Convertible Preferred Shares [Member]        
Related Party Transaction [Line Items]        
Legal and consulting costs     200  
Dr. Emmanuelle Charpentier [Member] | TRACR Hematology Limited [Member]        
Related Party Transaction [Line Items]        
Payment of consulting, licensing and other fees     1,000 34
Related party transaction additional fees     500 1,000
Bayer Healthcare LLC [Member]        
Related Party Transaction [Line Items]        
Issuance of convertible loans     35,000  
Bayer Healthcare LLC [Member] | Casebia Therapeutics LLP [Member]        
Related Party Transaction [Line Items]        
Revenue related to research and development services     1,200 $ 0
Bayer Global Investments B.V [Member]        
Related Party Transaction [Line Items]        
Proceeds from issuance of common shares in private placement   $ 35,000 $ 35,000  
Bayer Global Investments B.V [Member] | Private Placement [Member]        
Related Party Transaction [Line Items]        
Purchase of common shares 2,500,000 2,500,000 2,500,000