X0306 4 2023-03-14 0 0001674416 CRISPR Therapeutics AG CRSP 0001968317 Prasad Raju C/O CRISPR THERAPEUTICS, INC. 105 WEST FIRST STREET BOSTON MA 02127 0 1 0 0 Chief Financial Officer Restricted Stock Units 2023-03-14 4 A 0 40000 0.00 A Common Shares 40000 40000 D Stock Option (Right to Buy) 45.15 2023-03-14 4 A 0 100000 0.00 A 2033-03-14 Common Shares 100000 100000 D Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. This restricted stock unit award was granted on March 14, 2023 with respect to 40,000 Common Shares, with (i) one quarter of the shares vesting on March 14, 2024, (ii) one quarter of the shares vesting on March 14, 2025, (iii) one quarter of the shares vesting on March 14, 2026, and (iv) one quarter of the shares vesting on March 14, 2027. This option was granted on March 14, 2023 with respect to 100,000 Common Shares, with 25% of the shares vesting on March 14, 2024 and the remaining shares vesting on each monthly anniversary thereafter for a period of 36 months. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2023-03-14