X0306 4 2023-03-10 0 0001674416 CRISPR Therapeutics AG CRSP 0001928989 Morrow Phuong Khanh C/O CRISPR THERAPEUTICS, INC. 105 W FIRST STREET BOSTON MA 02127 0 1 0 0 Chief Medical Officer Stock Option (Right to Buy) 43.22 2023-03-10 4 A 0 44620 0.00 A 2033-03-10 Common Shares 44620 44620 D Restricted Stock Units 2023-03-10 4 A 0 22000 0.00 A Common Shares 22000 22000 D This option was granted on March 10, 2023 with respect to 44,620 Common Shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of April 10, 2023. Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. This restricted stock unit award was granted on March 10, 2023 with respect to 22,000 Common Shares, with (i) one quarter of the shares vesting on March 10, 2024, (ii) one quarter of the shares vesting on March 10, 2025, (iii) one quarter of the shares vesting on March 10, 2026, and (iv) one quarter of the shares vesting on March 10, 2027. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2023-03-14