X0306 4 2022-10-14 0 0001674416 CRISPR Therapeutics AG CRSP 0001857492 Smith Brendan C/O CRISPR THERAPEUTICS, INC. 105 W FIRST STREET BOSTON MA 02127 0 1 0 0 Chief Financial Officer Common Shares 2022-10-14 4 M 0 3750 A 3750 D Common Shares 2022-10-17 4 F 0 1111 55.76 D 2639 D Restricted Stock Units 2022-10-14 4 M 0 3750 A Common Shares 3750 11250 D The restriced stock units shall vest as follows: (i) one quarter of the shares shall vest on October 14, 2022, (ii) one quarter of the shares shall vest on October 14, 2023, (iii) one quarter of the shares shall vest on October 14, 2024, and (iv) one quarter of the shares shall vest on October 14, 2025. Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. On October 14, 2021, the reporting person was granted 15,000 restricted stock units. On October 14, 2022, 3,750 restricted stock units vested. Amount reported represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of these restricted stock units. This sale is mandated by the Company's RSU Settlement Policy to fund the tax withholding obligation and does not represent a discretionary trade by the reporting person. /s/ Elizabeth Ryland Waldinger, attorney-in-fact 2022-10-18