X0306 4 2022-03-10 0 0001674416 CRISPR Therapeutics AG CRSP 0001762583 Klein Lawrence Otto C/O CRISPR THERAPEUTICS, INC. 610 MAIN STREET CAMBRIDGE MA 02139 0 1 0 0 CBO & COO Common Shares 2022-03-10 4 M 0 4584 A 26909 D Common Shares 2022-03-11 4 F 0 1883 62.56 D 25026 D Common Shares 2022-03-11 4 M 0 3000 A 28026 D Common Shares 2022-03-14 4 F 0 1229 61.08 D 26797 D Restricted Stock Units 2022-03-10 4 M 0 4584 D Common Shares 4584 4583 D Restricted Stock Units 2022-03-11 4 M 0 3000 D Common Shares 3000 9000 D Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. Amount reported represents the number of shares required to be sold by the reporting person to cover the tax withholding obligation in connection with the vesting of these restricted stock units. This sale is mandated by the Company's RSU Settlement Policy to fund the tax withholding obligation and does not represent a discretionary trade by the reporting person. This restricted stock unit award was granted on March 10, 2020 with respect to 13,750 Common Shares, with (i) one third of the shares vesting on March 10, 2021, (ii) one third of the shares vesting on March 10, 2022, and (iii) one third of the shares vesting on March 10, 2023. This restricted stock unit award was granted on March 11, 2021 with respect to 12,000 Common Shares, with (i) one quarter of the shares vesting on March 11, 2022, (ii) one quarter of the shares vesting on March 11, 2023, (iii) one quarter of the shares vesting on March 11, 2024 and (iv) one quarter of the shares vesting on March 11, 2025. /s/ Michael Esposito, attorney-in-fact 2022-03-14