X0306 4 2022-02-18 0 0001674416 CRISPR Therapeutics AG CRSP 0001762583 Klein Lawrence Otto C/O CRISPR THERAPEUTICS, INC. 610 MAIN STREET CAMBRIDGE MA 02139 0 1 0 0 CBO & COO Stock Option (Right to Buy) 58.29 2022-02-18 4 A 0 46200 0.00 A 2032-02-18 Common Shares 46200 46200 D Restricted Stock Units 2022-02-18 4 A 0 20400 0.00 A Common Shares 20400 20400 D This option was granted on February 18, 2022 with respect to 46,200 Common Shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of March 18, 2022. Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. This restricted stock unit award was granted on February 18, 2022 with respect to 20,400 Common Shares, with (i) one quarter of the shares vesting on February 18, 2023, (ii) one quarter of the shares vesting on February 18, 2024, (iii) one quarter of the shares vesting on February 18, 2025, and (iv) one quarter of the shares vesting on February 18, 2026. /s/ Michael Esposito, attorney-in-fact 2022-02-22