X0306 4 2020-08-13 0 0001674416 CRISPR Therapeutics AG CRSP 0001613867 Behbahani Ali 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 1 0 0 0 Common Stock 2020-08-13 4 J 0 57 0.00 A 256 D Common Stock 2020-08-13 4 J 0 14 0.00 A 14 I See Note 3 NEA Partners 15, L.P. ("NEA Partners 15") made a pro rata distribution for no consideration of shares of Common Stock of the Issuer to its limited partners on August 13, 2020. The Reporting Person received 57 shares of Common Stock of the Issuer in the distribution by NEA Partners 15 on August 13, 2020. The Ali Behbahani Revocable Trust Dated June 26, 2015 (the "Behbahani Trust") received 14 shares of Common Stock of the Issuer in the distribution by NEA Partners 15 on August 13, 2020. The Reporting Person is the trustee of the Behbahani Trust, which is the direct beneficial owner of the securities. The Reporting Person disclaims beneficial ownership within the meaning of Section 16 of the 1934 Act, as amended, of such portion of the shares of Common Stock of the Issuer held by the Behbahani Trust in which the Reporting Person has no pecuniary interest. /s/ Sasha Keough, attorney-in-fact 2020-08-14