X0306 4 2020-03-10 0 0001674416 CRISPR Therapeutics AG CRSP 0001570392 TOMSICEK MICHAEL JOHN C/O CRISPR THERAPEUTICS, INC. 610 MAIN STREET CAMBRIDGE MA 02139 0 1 0 0 Chief Financial Officer Stock Option (Right to Buy) 44.67 2020-03-10 4 A 0 35000 0.00 A 2030-03-10 Common Shares 35000 35000 D Restricted Stock Units 2020-03-10 4 A 0 8500 0.00 A Common Shares 8500 8500 D This option was granted on March 10, 2020 with respect to 35,000 Common Shares. 100% of the shares will vest in 48 equal monthly installments, with the first vesting date of April 10, 2020. Each restricted stock unit represents a contingent right to receive one share of CRSP Common Shares. This restricted stock unit award was granted on March 10, 2020 with respect to 8,500 Common Shares, with (i) one third of the shares vesting on March 10, 2021, (ii) one third of the shares shares vesting on March 10, 2022, and (iii) one third of the shares vesting on March 10, 2023. /s/ Michael Esposito, attorney-in-fact 2020-03-12