X0306 4 2018-05-14 0 0001674416 CRISPR Therapeutics AG CRSP 0001613867 Behbahani Ali 1954 GREENSPRING DRIVE SUITE 600 TIMONIUM MD 21093 1 0 0 0 Common Stock 2018-05-14 4 J 0 199 0.00 A 199 D NEA Partners 15, L.P. ("NEA Partners 15") made a pro rata distribution for no consideration of an aggregate of 20,879 shares of Common Stock of the Issuer to its limited partners on May 14, 2018. The Reporting Person received 199 shares of Common Stock of the Issuer in the distribution by NEA Partners 15 on May 14, 2018. /s/ Sasha Keough, attorney-in-fact 2018-05-15