Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Common Shares [Member]	Treasury Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive (Loss) Income [Member]
Beginning balance at Dec. 31, 2021	$ 2,399,460	$ 2,391	$ (63)	$ 2,598,114	$ (195,915)	$ (5,067)
Beginning balance (in shares) at Dec. 31, 2021		76,990,066	180,316
Issuance of common shares, net of issuance costs	970			970
Issuance of common shares, net of issuance costs (in shares)		12,365
Vesting of restricted shares	8	$ 8
Vesting of restricted shares (in shares)		237,932
Exercise of vested options, net of issuance costs	35,813	$ 42		35,771
Exercise of vested options, net of issuance costs (in shares)		1,235,528
Purchase of common stock under ESPP	2,036			2,036
Purchase of common stock under ESPP (in shares)		36,559
Stock-based compensation expense	97,947			97,947
Other comprehensive loss	(10,580)					(10,580)
Net loss	(650,175)				(650,175)
Ending balance at Dec. 31, 2022	1,875,479	$ 2,441	$ (63)	2,734,838	(846,090)	(15,647)
Ending balance (in shares) at Dec. 31, 2022		78,512,450	180,316
Issuance of common shares, net of issuance costs	32,394	$ 15		32,379
Issuance of common shares, net of issuance costs (in shares)		458,547
Vesting of restricted shares	10	$ 10
Vesting of restricted shares (in shares)		277,808
Exercise of vested options, net of issuance costs	28,103	$ 31	$ 1	28,071
Exercise of vested options, net of issuance costs (in shares)		742,291	(10,000)
Purchase of common stock under ESPP	1,839			1,839
Purchase of common stock under ESPP (in shares)		53,282
Stock-based compensation expense	81,028			81,028
Other comprehensive loss	17,560					17,560
Net loss	(153,610)				(153,610)
Ending balance at Dec. 31, 2023	1,882,803	$ 2,497	$ (62)	2,878,155	(999,700)	1,913
Ending balance (in shares) at Dec. 31, 2023		80,044,378	170,316
Issuance of common shares, net of issuance costs	297,702	$ 145		297,557
Issuance of common shares, net of issuance costs (in shares)		4,309,521
Vesting of restricted shares	16	$ 16
Vesting of restricted shares (in shares)		450,701
Exercise of vested options, net of issuance costs	$ 29,579	$ 40		29,539
Exercise of vested options, net of issuance costs (in shares)	900,136	900,136
Purchase of common stock under ESPP	$ 1,738			1,738
Purchase of common stock under ESPP (in shares)		37,245
Stock-based compensation expense	86,567			86,567
Other comprehensive loss	(73)					(73)
Net loss	(366,252)				(366,252)
Ending balance at Dec. 31, 2024	$ 1,932,080	$ 2,698	$ (62)	$ 3,293,556	$ (1,365,952)	$ 1,840
Ending balance (in shares) at Dec. 31, 2024		85,741,981	170,316