Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2024	Dec. 31, 2023	Dec. 31, 2022
Revenue:
Total revenue	$ 37,314	$ 371,206	$ 1,198
Operating expenses:
Research and development	320,653	387,332	461,645
General and administrative	72,977	76,162	102,464
Collaboration expense, net	110,250	130,250	110,250
Total operating expenses	503,880	593,744	674,359
Loss from operations	(466,566)	(222,538)	(673,161)
Other income
Other income, net	103,901	71,816	22,661
Total other income, net	103,901	71,816	22,661
Net loss before income taxes	(362,665)	(150,722)	(650,500)
(Provision) benefit for income taxes	(3,587)	(2,888)	325
Net loss	(366,252)	(153,610)	(650,175)
Foreign currency translation adjustment	(21)	73	(80)
Unrealized (loss) gain on marketable securities	(52)	17,487	(10,500)
Comprehensive loss	$ (366,325)	$ (136,050)	$ (660,755)
Net loss per common share - basic	$ (4.34)	$ (1.94)	$ (8.36)
Basic weighted-average common shares outstanding	84,359,126	79,220,930	77,746,575
Net loss per common share - diluted	$ (4.34)	$ (1.94)	$ (8.36)
Diluted weighted-average common shares outstanding	84,359,126	79,220,930	77,746,575
Collaboration Revenue [Member]
Revenue:
Total revenue	$ 35,000	$ 370,000	$ 436
Grant Revenue [Member]
Revenue:
Total revenue	$ 2,314	$ 1,206	$ 762