Consolidated Statements of Shareholders' Equity - USD ($) $ in Thousands	Total	Common Shares [Member]	Treasury Shares [Member]	Additional Paid-in Capital [Member]	Accumulated Deficit [Member]	Accumulated Other Comprehensive (Loss) Income [Member]
Beginning balance at Dec. 31, 2020	$ 1,664,234	$ 2,277	$ (63)	$ 2,235,679	$ (573,576)	$ (83)
Beginning balance (in shares) at Dec. 31, 2020		73,914,844	195,316
Issuance of common shares, net of issuance costs	222,175	$ 45		222,130
Issuance of common shares, net of issuance costs (in shares)		1,353,121
Vesting of restricted shares	15	$ 15
Vesting of restricted shares (in shares)		455,440
Exercise of vested options, net of issuance costs	35,874	$ 54		35,820
Exercise of vested options, net of issuance costs (in shares)		1,245,071	(15,000)
Purchase of common stock under ESPP	2,095			2,095
Purchase of common stock under ESPP (in shares)		21,590
Stock-based compensation expense	102,390			102,390
Other comprehensive income (loss)	(4,984)					(4,984)
Net income (loss)	377,661				377,661
Ending balance at Dec. 31, 2021	2,399,460	$ 2,391	$ (63)	2,598,114	(195,915)	(5,067)
Ending balance (in shares) at Dec. 31, 2021		76,990,066	180,316
Issuance of common shares, net of issuance costs	970			970
Issuance of common shares, net of issuance costs (in shares)		12,365
Vesting of restricted shares	8	$ 8
Vesting of restricted shares (in shares)		237,932
Exercise of vested options, net of issuance costs	35,813	$ 42		35,771
Exercise of vested options, net of issuance costs (in shares)		1,235,528
Purchase of common stock under ESPP	2,036			2,036
Purchase of common stock under ESPP (in shares)		36,559
Stock-based compensation expense	97,947			97,947
Other comprehensive income (loss)	(10,580)					(10,580)
Net income (loss)	(650,175)				(650,175)
Ending balance at Dec. 31, 2022	1,875,479	$ 2,441	$ (63)	2,734,838	(846,090)	(15,647)
Ending balance (in shares) at Dec. 31, 2022		78,512,450	180,316
Issuance of common shares, net of issuance costs	32,394	$ 15		32,379
Issuance of common shares, net of issuance costs (in shares)		458,547
Vesting of restricted shares	10	$ 10
Vesting of restricted shares (in shares)		277,808
Exercise of vested options, net of issuance costs	$ 28,103	$ 31	$ 1	28,071
Exercise of vested options, net of issuance costs (in shares)	742,291	742,291	(10,000)
Purchase of common stock under ESPP	$ 1,839			1,839
Purchase of common stock under ESPP (in shares)		53,282
Stock-based compensation expense	81,028			81,028
Other comprehensive income (loss)	17,560					17,560
Net income (loss)	(153,610)				(153,610)
Ending balance at Dec. 31, 2023	$ 1,882,803	$ 2,497	$ (62)	$ 2,878,155	$ (999,700)	$ 1,913
Ending balance (in shares) at Dec. 31, 2023		80,044,378	170,316