Consolidated Statements of Operations and Comprehensive (Loss) Income - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Revenue:
Total revenue	$ 1,198	$ 914,963	$ 719
Operating expenses:
Research and development	461,645	340,567	221,382
General and administrative	102,464	99,690	85,747
Collaboration expense, net	110,250	101,178	48,025
Total operating expenses	674,359	541,435	355,154
(Loss) income from operations	(673,161)	373,528	(354,435)
Other income
Other income, net	22,661	6,003	6,379
Total other income, net	22,661	6,003	6,379
Net income (loss) before income taxes	(650,500)	379,531	(348,056)
Benefit (provision) for income taxes	325	(1,870)	(809)
Net (loss) income	(650,175)	377,661	(348,865)
Foreign currency translation adjustment	(80)	(11)	40
Unrealized loss on marketable securities	(10,500)	(4,973)	(130)
Comprehensive (loss) income	$ (660,755)	$ 372,677	$ (348,955)
Net (loss) income per common share - basic	$ (8.36)	$ 4.97	$ (5.29)
Basic weighted-average common shares outstanding	77,746,575	75,948,686	65,949,672
Net (loss) income per common share - diluted	$ (8.36)	$ 4.70	$ (5.29)
Diluted weighted-average common shares outstanding	77,746,575	80,393,496	65,949,672
Collaboration Revenue [Member]
Revenue:
Total revenue	$ 436	$ 913,081	$ 543
Grant Revenue [Member]
Revenue:
Total revenue	$ 762	$ 1,882	$ 176