Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	9 Months Ended
	Sep. 30, 2022	Sep. 30, 2021
Operating activities:
Net (loss) income	$ (539,600)	$ 518,909
Reconciliation of net (loss) income to net cash used in operating activities:
Depreciation and amortization	18,326	11,692
Equity-based compensation	75,142	76,622
Other non-cash items, net	12,251	9,420
Changes in:
Accounts receivable	256	(8)
Prepaid expenses and other assets	7,062	(18,775)
Accounts payable and accrued expenses	36,261	14,733
Deferred revenue	(762)	(779)
Operating lease assets and liabilities	10,826	19,679
Other liabilities, net	(2,175)	(6,483)
Net cash (used in) provided by operating activities	(382,413)	625,010
Investing activities:
Purchase of property, plant and equipment	(30,997)	(72,522)
Purchases of marketable securities	(923,404)	(1,386,785)
Maturities of marketable securities	871,278	432,593
Net cash used in investing activities	(83,123)	(1,026,714)
Financing activities:
Proceeds from issuance of common shares, net of issuance costs	970	213,267
Proceeds from exercise of options and ESPP contributions, net of issuance costs	35,144	31,379
Net cash provided by financing activities	36,114	244,646
Effect of exchange rate changes on cash	(195)	(14)
Decrease in cash	(429,617)	(157,072)
Cash, cash equivalents and restricted cash, beginning of period	939,944	1,185,468
Cash, cash equivalents and restricted cash, end of period	510,327	1,028,396
Supplemental disclosure of non-cash investing and financing activities
Property and equipment purchases in accounts payable and accrued expenses	4,919	6,264
Equity issuance costs in accounts payable and accrued expenses	299	$ 391
Leasehold improvements paid directly by landlord	$ 19,252